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Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells.
Cancer Res. 1997 Mar 01; 57(5):881-90.CR

Abstract

Vitamin E succinate (VES), a derivative of the fat-soluble vitamin D-alpha-tocopherol (vitamin E), inhibited growth and induced apoptotic cell death of estrogen receptor-negative human breast cancer cells. VES-induced apoptosis in MDA-MB-231 and SKBR-3 cells occurred through a Fas pathway. Total protein levels of the Fas receptor (Fas; APO-1/CD-95) and the Fas ligand (Fas-L) were increased following VES treatment. In addition, VES increased cell surface Fas expression. Fas-neutralizing antibodies and Fas-L antisense oligonucleotides blocked VES-induced apoptosis. The presence of Fas-L antisense oligonucleotides also completely blocked the VES-mediated increase in Fas-L protein expression. These data indicate a role for Fas signaling in VES-mediated apoptotic cell death of human breast cancer cells. These findings also suggest that VES may be of clinical use in the treatment of aggressive human breast cancers, particularly those that are refractory to antiestrogen therapy.

Authors+Show Affiliations

Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute, Frederick, Maryland 21702, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9041190

Citation

Turley, J M., et al. "Vitamin E Succinate Induces Fas-mediated Apoptosis in Estrogen Receptor-negative Human Breast Cancer Cells." Cancer Research, vol. 57, no. 5, 1997, pp. 881-90.
Turley JM, Fu T, Ruscetti FW, et al. Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. Cancer Res. 1997;57(5):881-90.
Turley, J. M., Fu, T., Ruscetti, F. W., Mikovits, J. A., Bertolette, D. C., & Birchenall-Roberts, M. C. (1997). Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. Cancer Research, 57(5), 881-90.
Turley JM, et al. Vitamin E Succinate Induces Fas-mediated Apoptosis in Estrogen Receptor-negative Human Breast Cancer Cells. Cancer Res. 1997 Mar 1;57(5):881-90. PubMed PMID: 9041190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. AU - Turley,J M, AU - Fu,T, AU - Ruscetti,F W, AU - Mikovits,J A, AU - Bertolette,D C,3rd AU - Birchenall-Roberts,M C, PY - 1997/3/1/pubmed PY - 2001/3/28/medline PY - 1997/3/1/entrez SP - 881 EP - 90 JF - Cancer research JO - Cancer Res. VL - 57 IS - 5 N2 - Vitamin E succinate (VES), a derivative of the fat-soluble vitamin D-alpha-tocopherol (vitamin E), inhibited growth and induced apoptotic cell death of estrogen receptor-negative human breast cancer cells. VES-induced apoptosis in MDA-MB-231 and SKBR-3 cells occurred through a Fas pathway. Total protein levels of the Fas receptor (Fas; APO-1/CD-95) and the Fas ligand (Fas-L) were increased following VES treatment. In addition, VES increased cell surface Fas expression. Fas-neutralizing antibodies and Fas-L antisense oligonucleotides blocked VES-induced apoptosis. The presence of Fas-L antisense oligonucleotides also completely blocked the VES-mediated increase in Fas-L protein expression. These data indicate a role for Fas signaling in VES-mediated apoptotic cell death of human breast cancer cells. These findings also suggest that VES may be of clinical use in the treatment of aggressive human breast cancers, particularly those that are refractory to antiestrogen therapy. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9041190/Vitamin_E_succinate_induces_Fas_mediated_apoptosis_in_estrogen_receptor_negative_human_breast_cancer_cells_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9041190 DB - PRIME DP - Unbound Medicine ER -