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Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5.
Arch Dermatol. 1997 Feb; 133(2):203-6.AD

Abstract

BACKGROUND

Peripheral and tissue eosinophilia are associated with a group of idiopathic inflammatory syndromes. The idiopathic hypereosinophilic syndrome represents a spectrum of disorders characterized by prolonged eosinophilia of an undetectable cause and significant organ dysfunction. The pathogenic role of the eosinophil in these conditions is attested to by evidence of eosinophil activation and degranulation at sites of tissue injury. Recently, an overlapping range of idiopathic eosinophilic muscle disease with an overall good prognosis has been described.

RESULTS

We describe a patient with a syndrome of idiopathic myositis with eosinophilia and eosinophilic cellulitislike cutaneous manifestations. Histopathological studies of the skin and muscle revealed eosinophilic infiltration. Elevated serum levels of eosinophilic cationic protein and interleukin-5 paralleling disease activity were detected.

CONCLUSIONS

This patient demonstrates clinical and laboratory features of eosinophilic myositis with eosinophilic cellulitislike skin lesions. The elevated serum levels of interleukin-5 and eosinophilic cationic protein may be responsible for the eosinophilia and tissue injury, respectively. With the advances in our understanding of cytokine-dependent regulatory mechanisms governing the eosinophil reaction, more targeted ways of manipulating eosinophilia as well as the entry and activation of eosinophils within specific tissues can be expected.

Authors+Show Affiliations

Department of Dermatology, University Hospital of Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9041834

Citation

Trüeb, R M., et al. "Eosinophilic Myositis With Eosinophilic Cellulitislike Skin Lesions. Association With Increased Serum Levels of Eosinophil Cationic Protein and Interleukin-5." Archives of Dermatology, vol. 133, no. 2, 1997, pp. 203-6.
Trüeb RM, Lübbe J, Torricelli R, et al. Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5. Arch Dermatol. 1997;133(2):203-6.
Trüeb, R. M., Lübbe, J., Torricelli, R., Panizzon, R. G., Wüthrich, B., & Burg, G. (1997). Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5. Archives of Dermatology, 133(2), 203-6.
Trüeb RM, et al. Eosinophilic Myositis With Eosinophilic Cellulitislike Skin Lesions. Association With Increased Serum Levels of Eosinophil Cationic Protein and Interleukin-5. Arch Dermatol. 1997;133(2):203-6. PubMed PMID: 9041834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5. AU - Trüeb,R M, AU - Lübbe,J, AU - Torricelli,R, AU - Panizzon,R G, AU - Wüthrich,B, AU - Burg,G, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 203 EP - 6 JF - Archives of dermatology JO - Arch Dermatol VL - 133 IS - 2 N2 - BACKGROUND: Peripheral and tissue eosinophilia are associated with a group of idiopathic inflammatory syndromes. The idiopathic hypereosinophilic syndrome represents a spectrum of disorders characterized by prolonged eosinophilia of an undetectable cause and significant organ dysfunction. The pathogenic role of the eosinophil in these conditions is attested to by evidence of eosinophil activation and degranulation at sites of tissue injury. Recently, an overlapping range of idiopathic eosinophilic muscle disease with an overall good prognosis has been described. RESULTS: We describe a patient with a syndrome of idiopathic myositis with eosinophilia and eosinophilic cellulitislike cutaneous manifestations. Histopathological studies of the skin and muscle revealed eosinophilic infiltration. Elevated serum levels of eosinophilic cationic protein and interleukin-5 paralleling disease activity were detected. CONCLUSIONS: This patient demonstrates clinical and laboratory features of eosinophilic myositis with eosinophilic cellulitislike skin lesions. The elevated serum levels of interleukin-5 and eosinophilic cationic protein may be responsible for the eosinophilia and tissue injury, respectively. With the advances in our understanding of cytokine-dependent regulatory mechanisms governing the eosinophil reaction, more targeted ways of manipulating eosinophilia as well as the entry and activation of eosinophils within specific tissues can be expected. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/9041834/Eosinophilic_myositis_with_eosinophilic_cellulitislike_skin_lesions__Association_with_increased_serum_levels_of_eosinophil_cationic_protein_and_interleukin_5_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/133/pg/203 DB - PRIME DP - Unbound Medicine ER -