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Effectiveness of influenza vaccine in reducing hospital admissions during the 1989-90 epidemic.

Abstract

The effectiveness of influenza vaccine in reducing hospital admissions for pneumonia, influenza, bronchitis, or emphysema was assessed by a case-control study of people aged 16 years and older who were admitted to 10 Leicestershire hospitals between 1 December 1989 and 31 January 1990. Hospital and general practitioners' records for 156 admissions (the cases) and 289 controls matched for age and sex were reviewed. Information was collected on demography, the usual place of residence (institutional or non-institutional), the existence of chronic illness, and vaccination during the 5 years before admission. The odds ratio for hospital admission among vaccinees was 0.67 (95% CI 0.39-1.12) giving an estimate of vaccine effectiveness in this setting of 33% (95% CI 0-61). However, multivariate logistic regression, adjusting for the effects of institutional care and chronic illness, revealed that influenza vaccination reduced hospital admissions by 63% (95% CI 17-84%). There was a strong trend towards improved vaccine effectiveness when used in institutional settings. Influenza vaccine is effective in reducing hospital admissions for influenza, pneumonia, bronchitis and emphysema, and effectiveness is comparable to that observed for influenza and pneumonia admissions in North America.

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  • Authors+Show Affiliations

    ,

    Department of Microbiology and Immunology, School of Medicine, Leicester University, UK.

    , ,

    Source

    Epidemiology and infection 118:1 1997 Feb pg 27-33

    MeSH

    Adolescent
    Adult
    Aged
    Bronchitis
    Case-Control Studies
    Chronic Disease
    Emphysema
    England
    Female
    Hospitalization
    Humans
    Influenza A virus
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Patient Admission
    Pneumonia, Viral
    Regression Analysis
    Risk Factors
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9042032

    Citation

    Ahmed, A H., et al. "Effectiveness of Influenza Vaccine in Reducing Hospital Admissions During the 1989-90 Epidemic." Epidemiology and Infection, vol. 118, no. 1, 1997, pp. 27-33.
    Ahmed AH, Nicholson KG, Nguyen-van Tam JS, et al. Effectiveness of influenza vaccine in reducing hospital admissions during the 1989-90 epidemic. Epidemiol Infect. 1997;118(1):27-33.
    Ahmed, A. H., Nicholson, K. G., Nguyen-van Tam, J. S., & Pearson, J. C. (1997). Effectiveness of influenza vaccine in reducing hospital admissions during the 1989-90 epidemic. Epidemiology and Infection, 118(1), pp. 27-33.
    Ahmed AH, et al. Effectiveness of Influenza Vaccine in Reducing Hospital Admissions During the 1989-90 Epidemic. Epidemiol Infect. 1997;118(1):27-33. PubMed PMID: 9042032.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness of influenza vaccine in reducing hospital admissions during the 1989-90 epidemic. AU - Ahmed,A H, AU - Nicholson,K G, AU - Nguyen-van Tam,J S, AU - Pearson,J C, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 27 EP - 33 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 118 IS - 1 N2 - The effectiveness of influenza vaccine in reducing hospital admissions for pneumonia, influenza, bronchitis, or emphysema was assessed by a case-control study of people aged 16 years and older who were admitted to 10 Leicestershire hospitals between 1 December 1989 and 31 January 1990. Hospital and general practitioners' records for 156 admissions (the cases) and 289 controls matched for age and sex were reviewed. Information was collected on demography, the usual place of residence (institutional or non-institutional), the existence of chronic illness, and vaccination during the 5 years before admission. The odds ratio for hospital admission among vaccinees was 0.67 (95% CI 0.39-1.12) giving an estimate of vaccine effectiveness in this setting of 33% (95% CI 0-61). However, multivariate logistic regression, adjusting for the effects of institutional care and chronic illness, revealed that influenza vaccination reduced hospital admissions by 63% (95% CI 17-84%). There was a strong trend towards improved vaccine effectiveness when used in institutional settings. Influenza vaccine is effective in reducing hospital admissions for influenza, pneumonia, bronchitis and emphysema, and effectiveness is comparable to that observed for influenza and pneumonia admissions in North America. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/9042032/Effectiveness_of_influenza_vaccine_in_reducing_hospital_admissions_during_the_1989_90_epidemic_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9042032/ DB - PRIME DP - Unbound Medicine ER -