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Determination of amphetamine and methylenedioxy-amphetamine-derivatives in hair.
Forensic Sci Int. 1997 Jan 17; 84(1-3):179-88.FS

Abstract

Two GC/MS-procedures for the detection of amphetamine and its methylenedioxy-derivatives (MDA, MDMA and MDE) in hair are presented. In these methods a methanol sonication extraction technique was applied. The extracted drugs were derivatized either with propionic acid anhydride (PSA) or trifluoroacetic acid anhydride (TFA). PSA-derivatives are more stable than TFA-derivatives, but the latter provide more specific mass-spectrometric information, and, therefore, seem to be preferably for amphetamine determination. The detection limit for all compounds was in a range of about 0.01 ng/mg, if at least 50-100 mg of hair were analyzed, independent of the derivatization used.

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Authors+Show Affiliations

Röhrich J
Zentrum der Rechtsmedizin, Johann Wolfgang Goethe-University Frankfurt, Germany.
Kauert G
No affiliation info available

MeSH

3,4-MethylenedioxyamphetamineAmphetamineCentral Nervous System StimulantsGas Chromatography-Mass SpectrometryHairHallucinogensHumansSubstance Abuse Detection

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9042723

Citation

Röhrich, J, and G Kauert. "Determination of Amphetamine and Methylenedioxy-amphetamine-derivatives in Hair." Forensic Science International, vol. 84, no. 1-3, 1997, pp. 179-88.
Röhrich J, Kauert G. Determination of amphetamine and methylenedioxy-amphetamine-derivatives in hair. Forensic Sci Int. 1997;84(1-3):179-88.
Röhrich, J., & Kauert, G. (1997). Determination of amphetamine and methylenedioxy-amphetamine-derivatives in hair. Forensic Science International, 84(1-3), 179-88.
Röhrich J, Kauert G. Determination of Amphetamine and Methylenedioxy-amphetamine-derivatives in Hair. Forensic Sci Int. 1997 Jan 17;84(1-3):179-88. PubMed PMID: 9042723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of amphetamine and methylenedioxy-amphetamine-derivatives in hair. AU - Röhrich,J, AU - Kauert,G, PY - 1997/1/17/pubmed PY - 1997/1/17/medline PY - 1997/1/17/entrez SP - 179 EP - 88 JF - Forensic science international JO - Forensic Sci Int VL - 84 IS - 1-3 N2 - Two GC/MS-procedures for the detection of amphetamine and its methylenedioxy-derivatives (MDA, MDMA and MDE) in hair are presented. In these methods a methanol sonication extraction technique was applied. The extracted drugs were derivatized either with propionic acid anhydride (PSA) or trifluoroacetic acid anhydride (TFA). PSA-derivatives are more stable than TFA-derivatives, but the latter provide more specific mass-spectrometric information, and, therefore, seem to be preferably for amphetamine determination. The detection limit for all compounds was in a range of about 0.01 ng/mg, if at least 50-100 mg of hair were analyzed, independent of the derivatization used. SN - 0379-0738 UR - https://www.unboundmedicine.com/medline/citation/9042723/Determination_of_amphetamine_and_methylenedioxy_amphetamine_derivatives_in_hair_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(96)02061-0 DB - PRIME DP - Unbound Medicine ER -