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The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes.
Immunopharmacology. 1997 Jan; 35(3):255-63.I

Abstract

Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay. When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response. The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro.

Authors+Show Affiliations

Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9043939

Citation

Leung, M Y., et al. "The Isolation and Characterization of an Immunomodulatory and Anti-tumor Polysaccharide Preparation From Flammulina Velutipes." Immunopharmacology, vol. 35, no. 3, 1997, pp. 255-63.
Leung MY, Fung KP, Choy YM. The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. Immunopharmacology. 1997;35(3):255-63.
Leung, M. Y., Fung, K. P., & Choy, Y. M. (1997). The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. Immunopharmacology, 35(3), 255-63.
Leung MY, Fung KP, Choy YM. The Isolation and Characterization of an Immunomodulatory and Anti-tumor Polysaccharide Preparation From Flammulina Velutipes. Immunopharmacology. 1997;35(3):255-63. PubMed PMID: 9043939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. AU - Leung,M Y, AU - Fung,K P, AU - Choy,Y M, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 255 EP - 63 JF - Immunopharmacology JO - Immunopharmacology VL - 35 IS - 3 N2 - Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay. When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response. The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro. SN - 0162-3109 UR - https://www.unboundmedicine.com/medline/citation/9043939/The_isolation_and_characterization_of_an_immunomodulatory_and_anti_tumor_polysaccharide_preparation_from_Flammulina_velutipes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0162310996001579 DB - PRIME DP - Unbound Medicine ER -