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Oxidative thymine dimer repair in the DNA helix.
Science. 1997 Mar 07; 275(5305):1465-8.Sci

Abstract

The metallointercalator Rh(phi)2DMB3+ (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4'-dimethyl-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening pi-stack.

Authors+Show Affiliations

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9045609

Citation

Dandliker, P J., et al. "Oxidative Thymine Dimer Repair in the DNA Helix." Science (New York, N.Y.), vol. 275, no. 5305, 1997, pp. 1465-8.
Dandliker PJ, Holmlin RE, Barton JK. Oxidative thymine dimer repair in the DNA helix. Science. 1997;275(5305):1465-8.
Dandliker, P. J., Holmlin, R. E., & Barton, J. K. (1997). Oxidative thymine dimer repair in the DNA helix. Science (New York, N.Y.), 275(5305), 1465-8.
Dandliker PJ, Holmlin RE, Barton JK. Oxidative Thymine Dimer Repair in the DNA Helix. Science. 1997 Mar 7;275(5305):1465-8. PubMed PMID: 9045609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative thymine dimer repair in the DNA helix. AU - Dandliker,P J, AU - Holmlin,R E, AU - Barton,J K, PY - 1997/3/7/pubmed PY - 1997/3/7/medline PY - 1997/3/7/entrez SP - 1465 EP - 8 JF - Science (New York, N.Y.) JO - Science VL - 275 IS - 5305 N2 - The metallointercalator Rh(phi)2DMB3+ (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4'-dimethyl-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening pi-stack. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/9045609/Oxidative_thymine_dimer_repair_in_the_DNA_helix_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=9045609 DB - PRIME DP - Unbound Medicine ER -