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[Molecular mechanism of lytic phase of Epstein-Barr virus DNA replication].
Nihon Rinsho. 1997 Feb; 55(2):321-7.NR

Abstract

Epstein-Barr virus(EBV) is a human herpesvirus with a linear double stranded DNA, 172 kbp in length. The EBV has both a latent state and a lytic replicative cycle. Latency replication is dependent on cellular DNA replication machinery except for a single EBV-encoded protein, EBNA1. The EBV genome is maintained as a circular plasmid molecule and ori P, the latent phase replication origin of EBV, mediates this type of replication. The immediate-early BZLF1 protein disrupts viral latency through transactivation of early EBV genes. After induction of the lytic phase of viral replication, the EBV genome is amplified 100- to 1000-fold. The replication product is a head to tail concatemer which is presumed to be synthesized via a rolling circle mechanism initiated from the lytic phase replication origin, ori Lyt. EBV encodes seven viral genes that are essential for ori Lyt-dependent DNA replication. A number of features of EBV DNA replication make it a unique model system for the study of eukaryotic DNA replication. Here, the molecular mechanism of the lytic phase of the EBV DNA replication is discussed.

Authors+Show Affiliations

Laboratory of Virology, Nagoya University School of Medicine.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

9046818

Citation

Tsurumi, T. "[Molecular Mechanism of Lytic Phase of Epstein-Barr Virus DNA Replication]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 55, no. 2, 1997, pp. 321-7.
Tsurumi T. [Molecular mechanism of lytic phase of Epstein-Barr virus DNA replication]. Nihon Rinsho. 1997;55(2):321-7.
Tsurumi, T. (1997). [Molecular mechanism of lytic phase of Epstein-Barr virus DNA replication]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 55(2), 321-7.
Tsurumi T. [Molecular Mechanism of Lytic Phase of Epstein-Barr Virus DNA Replication]. Nihon Rinsho. 1997;55(2):321-7. PubMed PMID: 9046818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Molecular mechanism of lytic phase of Epstein-Barr virus DNA replication]. A1 - Tsurumi,T, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 321 EP - 7 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nihon Rinsho VL - 55 IS - 2 N2 - Epstein-Barr virus(EBV) is a human herpesvirus with a linear double stranded DNA, 172 kbp in length. The EBV has both a latent state and a lytic replicative cycle. Latency replication is dependent on cellular DNA replication machinery except for a single EBV-encoded protein, EBNA1. The EBV genome is maintained as a circular plasmid molecule and ori P, the latent phase replication origin of EBV, mediates this type of replication. The immediate-early BZLF1 protein disrupts viral latency through transactivation of early EBV genes. After induction of the lytic phase of viral replication, the EBV genome is amplified 100- to 1000-fold. The replication product is a head to tail concatemer which is presumed to be synthesized via a rolling circle mechanism initiated from the lytic phase replication origin, ori Lyt. EBV encodes seven viral genes that are essential for ori Lyt-dependent DNA replication. A number of features of EBV DNA replication make it a unique model system for the study of eukaryotic DNA replication. Here, the molecular mechanism of the lytic phase of the EBV DNA replication is discussed. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/9046818/[Molecular_mechanism_of_lytic_phase_of_Epstein_Barr_virus_DNA_replication]_ DB - PRIME DP - Unbound Medicine ER -
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