Tags

Type your tag names separated by a space and hit enter

Evaluation of fasting plasma glucose as a screening test for diabetes mellitus in Singaporean adults.
Diabet Med. 1997 Feb; 14(2):119-22.DM

Abstract

To assess the performance of different cutoff points for fasting plasma glucose (FPG) including the World Health Organization (WHO) cutoff of FPG > and = 7.8 mmol l-1 for the screening of diabetes mellitus, data from oral glucose tolerance tests done on 865 Singaporean adults over a 4-year period were analysed. The relationship between FPG and 2 h post-load plasma glucose (2H-PG) was determined using regression analysis and receiver operating characteristic (ROC) analysis. Out of 220 subjects with 2H-PG exceeding 11.1 mmol l-1, only 90 had FPG exceeding 7.8 mmol l-1, yielding a sensitivity of only 40.9%. The relationship between FPG and 2H-PG was non-linear and conformed to a cubic equation [FPG = 3.0890 + 0.0272 (2H-PG)2 - 0.0006 (2H-PG)3]. ROC analysis determined an FPG of 5.7 mmol l-1 to yield optimal sensitivity and specificity. Although in the clinical setting, FPG is an extremely useful screening test for diabetes, it is clear, as has been shown in other studies, that the traditional WHO criterion of FPG > and = 7.8 mmol l-1 is highly insensitive for detecting diabetes. Lower FPG cutoffs achieve greater sensitivity albeit at the expense of reduced specificity. Although ROC analysis in this population determines the optimally sensitive and specific FPG cutoff to be 5.7 mmol l-1, we suggest that the FPG cutoff should be adjusted to 7.0 mmol l-1 for preservation of specificity.

Authors+Show Affiliations

Department of Medicine, Toa Payoh Hospital, Singapore.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9047088

Citation

Lee, C H., and S Fook-Chong. "Evaluation of Fasting Plasma Glucose as a Screening Test for Diabetes Mellitus in Singaporean Adults." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 14, no. 2, 1997, pp. 119-22.
Lee CH, Fook-Chong S. Evaluation of fasting plasma glucose as a screening test for diabetes mellitus in Singaporean adults. Diabet Med. 1997;14(2):119-22.
Lee, C. H., & Fook-Chong, S. (1997). Evaluation of fasting plasma glucose as a screening test for diabetes mellitus in Singaporean adults. Diabetic Medicine : a Journal of the British Diabetic Association, 14(2), 119-22.
Lee CH, Fook-Chong S. Evaluation of Fasting Plasma Glucose as a Screening Test for Diabetes Mellitus in Singaporean Adults. Diabet Med. 1997;14(2):119-22. PubMed PMID: 9047088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of fasting plasma glucose as a screening test for diabetes mellitus in Singaporean adults. AU - Lee,C H, AU - Fook-Chong,S, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 119 EP - 22 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 14 IS - 2 N2 - To assess the performance of different cutoff points for fasting plasma glucose (FPG) including the World Health Organization (WHO) cutoff of FPG > and = 7.8 mmol l-1 for the screening of diabetes mellitus, data from oral glucose tolerance tests done on 865 Singaporean adults over a 4-year period were analysed. The relationship between FPG and 2 h post-load plasma glucose (2H-PG) was determined using regression analysis and receiver operating characteristic (ROC) analysis. Out of 220 subjects with 2H-PG exceeding 11.1 mmol l-1, only 90 had FPG exceeding 7.8 mmol l-1, yielding a sensitivity of only 40.9%. The relationship between FPG and 2H-PG was non-linear and conformed to a cubic equation [FPG = 3.0890 + 0.0272 (2H-PG)2 - 0.0006 (2H-PG)3]. ROC analysis determined an FPG of 5.7 mmol l-1 to yield optimal sensitivity and specificity. Although in the clinical setting, FPG is an extremely useful screening test for diabetes, it is clear, as has been shown in other studies, that the traditional WHO criterion of FPG > and = 7.8 mmol l-1 is highly insensitive for detecting diabetes. Lower FPG cutoffs achieve greater sensitivity albeit at the expense of reduced specificity. Although ROC analysis in this population determines the optimally sensitive and specific FPG cutoff to be 5.7 mmol l-1, we suggest that the FPG cutoff should be adjusted to 7.0 mmol l-1 for preservation of specificity. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/9047088/Evaluation_of_fasting_plasma_glucose_as_a_screening_test_for_diabetes_mellitus_in_Singaporean_adults_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -