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Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA)
Cancer Causes Control 1997; 8(1):5-12CC

Abstract

A population-based interview study in Los Angeles County (California, USA) of 94 women with intracranial gliomas and 94 individually matched neighborhood controls investigated the relationship to various sources of exposure to N-nitroso compounds and their precursors and to vitamins which inhibit the endogenous formation of these compounds. The study offers some support for the hypothesis that dietary sources of nitroso exposure relate to risk. Risk increased with increasing consumption of cured meats, most notably of bacon (odds ratio [OR] for the third tertile of intake = 6.6, 95 percent confidence interval [CI] = 1.9-22.5, P trend < 0.001). Risk was reduced with increasing intake of vegetables such as bell peppers (OR for third tertile = 0.2, CI = 0.1-0.7, P trend < 0.01). In addition, use of vitamin supplements appeared protective, and there was some suggestion that eating cured meats in combination with foods which inhibit endogenous nitrosation mitigates risk. Other potential sources of nitroso exposure such as smoking, cosmetics, and drinking water did not relate to risk. Despite the limitations of data on usual adult diet, it appears that dietary sources of nitroso compounds may be important in the development of gliomas.

Authors+Show Affiliations

Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9051317

Citation

Blowers, L, et al. "Dietary and Other Lifestyle Factors of Women With Brain Gliomas in Los Angeles County (California, USA)." Cancer Causes & Control : CCC, vol. 8, no. 1, 1997, pp. 5-12.
Blowers L, Preston-Martin S, Mack WJ. Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA). Cancer Causes Control. 1997;8(1):5-12.
Blowers, L., Preston-Martin, S., & Mack, W. J. (1997). Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA). Cancer Causes & Control : CCC, 8(1), pp. 5-12.
Blowers L, Preston-Martin S, Mack WJ. Dietary and Other Lifestyle Factors of Women With Brain Gliomas in Los Angeles County (California, USA). Cancer Causes Control. 1997;8(1):5-12. PubMed PMID: 9051317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA) AU - Blowers,L, AU - Preston-Martin,S, AU - Mack,W J, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 5 EP - 12 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 8 IS - 1 N2 - A population-based interview study in Los Angeles County (California, USA) of 94 women with intracranial gliomas and 94 individually matched neighborhood controls investigated the relationship to various sources of exposure to N-nitroso compounds and their precursors and to vitamins which inhibit the endogenous formation of these compounds. The study offers some support for the hypothesis that dietary sources of nitroso exposure relate to risk. Risk increased with increasing consumption of cured meats, most notably of bacon (odds ratio [OR] for the third tertile of intake = 6.6, 95 percent confidence interval [CI] = 1.9-22.5, P trend < 0.001). Risk was reduced with increasing intake of vegetables such as bell peppers (OR for third tertile = 0.2, CI = 0.1-0.7, P trend < 0.01). In addition, use of vitamin supplements appeared protective, and there was some suggestion that eating cured meats in combination with foods which inhibit endogenous nitrosation mitigates risk. Other potential sources of nitroso exposure such as smoking, cosmetics, and drinking water did not relate to risk. Despite the limitations of data on usual adult diet, it appears that dietary sources of nitroso compounds may be important in the development of gliomas. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/9051317/Dietary_and_other_lifestyle_factors_of_women_with_brain_gliomas_in_Los_Angeles_County__California_USA_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9051317.ui DB - PRIME DP - Unbound Medicine ER -