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A prospective study of oral contraceptive use and risk of breast cancer (Nurses' Health Study, United States).

Abstract

Results of previous epidemiologic studies have provided reassurance that there is little, if any, increase in risk of breast cancer with oral contraceptive (OC) use in general. However, in several studies, an increased risk of breast cancer has been observed in two subgroups, young women who used OCs for extended durations and in women who used OCs prior to a first-term pregnancy. We evaluated these relationships using data from the ongoing Nurses' Health Study cohort (United States). We documented 3,383 cases of breast cancer from 1976 to 1992 among 1.6 million person-years of follow-up. We observed no overall relationship between duration of OC use and breast cancer risk, even among women who reported using OCs for 10 or more years (multivariate relative risk [RR] = 1.11, 95 percent confidence interval [CI] = 0.94-1.32). Among women less than 45 years of age, the multivariate RR for using OCs for 10 or more years was 1.07 (CI = 0.70-1.65) compared with never-users. The risk associated with five or more years of OC use prior to a first full-term pregnancy compared with never-use was 0.96 (CI = 0.65-1.43). Among women less than 45 years of age, we observed no evidence of an increased risk with OC use before a first full-term pregnancy (use for five or more years: RR = 0.57, CI = 0.24-1.31). Because of the age distribution of our cohort, we were unable to evaluate these relationships among women less than 40 years of age. Our study provides considerable evidence that long-term past OC use, either overall or prior to a first full-term pregnancy, does not result in any appreciable increase in breast cancer risk in women over 40 years of age.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.

    , , , , ,

    Source

    Cancer causes & control : CCC 8:1 1997 Jan pg 65-72

    MeSH

    Adult
    Breast Neoplasms
    Cohort Studies
    Contraceptives, Oral
    Female
    Humans
    Maternal Age
    Middle Aged
    Multivariate Analysis
    Parity
    Proportional Hazards Models
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9051324

    Citation

    Hankinson, S E., et al. "A Prospective Study of Oral Contraceptive Use and Risk of Breast Cancer (Nurses' Health Study, United States)." Cancer Causes & Control : CCC, vol. 8, no. 1, 1997, pp. 65-72.
    Hankinson SE, Colditz GA, Manson JE, et al. A prospective study of oral contraceptive use and risk of breast cancer (Nurses' Health Study, United States). Cancer Causes Control. 1997;8(1):65-72.
    Hankinson, S. E., Colditz, G. A., Manson, J. E., Willett, W. C., Hunter, D. J., Stampfer, M. J., & Speizer, F. E. (1997). A prospective study of oral contraceptive use and risk of breast cancer (Nurses' Health Study, United States). Cancer Causes & Control : CCC, 8(1), pp. 65-72.
    Hankinson SE, et al. A Prospective Study of Oral Contraceptive Use and Risk of Breast Cancer (Nurses' Health Study, United States). Cancer Causes Control. 1997;8(1):65-72. PubMed PMID: 9051324.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of oral contraceptive use and risk of breast cancer (Nurses' Health Study, United States). AU - Hankinson,S E, AU - Colditz,G A, AU - Manson,J E, AU - Willett,W C, AU - Hunter,D J, AU - Stampfer,M J, AU - Speizer,F E, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 65 EP - 72 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 8 IS - 1 N2 - Results of previous epidemiologic studies have provided reassurance that there is little, if any, increase in risk of breast cancer with oral contraceptive (OC) use in general. However, in several studies, an increased risk of breast cancer has been observed in two subgroups, young women who used OCs for extended durations and in women who used OCs prior to a first-term pregnancy. We evaluated these relationships using data from the ongoing Nurses' Health Study cohort (United States). We documented 3,383 cases of breast cancer from 1976 to 1992 among 1.6 million person-years of follow-up. We observed no overall relationship between duration of OC use and breast cancer risk, even among women who reported using OCs for 10 or more years (multivariate relative risk [RR] = 1.11, 95 percent confidence interval [CI] = 0.94-1.32). Among women less than 45 years of age, the multivariate RR for using OCs for 10 or more years was 1.07 (CI = 0.70-1.65) compared with never-users. The risk associated with five or more years of OC use prior to a first full-term pregnancy compared with never-use was 0.96 (CI = 0.65-1.43). Among women less than 45 years of age, we observed no evidence of an increased risk with OC use before a first full-term pregnancy (use for five or more years: RR = 0.57, CI = 0.24-1.31). Because of the age distribution of our cohort, we were unable to evaluate these relationships among women less than 40 years of age. Our study provides considerable evidence that long-term past OC use, either overall or prior to a first full-term pregnancy, does not result in any appreciable increase in breast cancer risk in women over 40 years of age. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/9051324/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9051324.ui DB - PRIME DP - Unbound Medicine ER -