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Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma.
J Allergy Clin Immunol. 1997 Mar; 99(3):330-7.JA

Abstract

BACKGROUND

Patients with asthma who have moderate to severe airway hyperresponsiveness often demonstrate progressive, unlimited airway narrowing in response to inhaled bronchoconstrictor stimuli, which is likely to be due to inflammatory changes within the airway wall. It is unknown whether regular therapy with inhaled steroids can limit this excessive response.

OBJECTIVE

We investigated the effect of inhaled budesonide on the development of a plateau on the dose-response curve to methacholine in patients with asthma who did not show such a plateau before the study.

METHODS

Thirty-one atopic patients with asthma (age, 19 to 31 years; FEV1 > 70% of predicted value; PC20 < 8 mg/ml) with documented absence of a maximal-response plateau to methacholine on two occasions during the run-in period, participated in a double-blind, placebo-controlled, parallel study. Standardized methacholine challenges were performed at -1, 0, 4, 8, and 12 weeks of treatment with inhaled budesonide, 800 microg two times a day, or corresponding placebo, and after a 2-week washout period. Airway response was measured by FEV1 (percent fall from baseline). A maximal-response plateau was considered if three or more consecutive data points fell within a 5% response range.

RESULTS

Thirty patients completed the study. There was a steady increase in the number of budesonide-treated patients exhibiting a maximal-response plateau on the dose-response curve from zero of 15 patients at run-in to nine of 14 patients at week 12, as compared with four of 16 patients in the placebo group (p = 0.03, chi square test). This was accompanied by a significant improvement in PC20 in the budesonide group as compared with the placebo group (p < 0.01 at week 12), whereas the changes in FEV1 were not significantly different between the groups (p = 0.77 at week 12).

CONCLUSION

Regular treatment with the inhaled corticosteroid budesonide limits maximal airway narrowing in response to methacholine by introducing a plateau on the dose-response curve in patients with asthma, who were initially characterized by the absence of a plateau. This indicates that inhaled steroids are likely to reduce the hazard of unlimited airway narrowing in asthma.

Authors+Show Affiliations

Department of Pulmonology, Leiden University Hospital, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9058688

Citation

Booms, P, et al. "Protective Effect of Inhaled Budesonide Against Unlimited Airway Narrowing to Methacholine in Atopic Patients With Asthma." The Journal of Allergy and Clinical Immunology, vol. 99, no. 3, 1997, pp. 330-7.
Booms P, Cheung D, Timmers MC, et al. Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma. J Allergy Clin Immunol. 1997;99(3):330-7.
Booms, P., Cheung, D., Timmers, M. C., Zwinderman, A. H., & Sterk, P. J. (1997). Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma. The Journal of Allergy and Clinical Immunology, 99(3), 330-7.
Booms P, et al. Protective Effect of Inhaled Budesonide Against Unlimited Airway Narrowing to Methacholine in Atopic Patients With Asthma. J Allergy Clin Immunol. 1997;99(3):330-7. PubMed PMID: 9058688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma. AU - Booms,P, AU - Cheung,D, AU - Timmers,M C, AU - Zwinderman,A H, AU - Sterk,P J, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 330 EP - 7 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 99 IS - 3 N2 - BACKGROUND: Patients with asthma who have moderate to severe airway hyperresponsiveness often demonstrate progressive, unlimited airway narrowing in response to inhaled bronchoconstrictor stimuli, which is likely to be due to inflammatory changes within the airway wall. It is unknown whether regular therapy with inhaled steroids can limit this excessive response. OBJECTIVE: We investigated the effect of inhaled budesonide on the development of a plateau on the dose-response curve to methacholine in patients with asthma who did not show such a plateau before the study. METHODS: Thirty-one atopic patients with asthma (age, 19 to 31 years; FEV1 > 70% of predicted value; PC20 < 8 mg/ml) with documented absence of a maximal-response plateau to methacholine on two occasions during the run-in period, participated in a double-blind, placebo-controlled, parallel study. Standardized methacholine challenges were performed at -1, 0, 4, 8, and 12 weeks of treatment with inhaled budesonide, 800 microg two times a day, or corresponding placebo, and after a 2-week washout period. Airway response was measured by FEV1 (percent fall from baseline). A maximal-response plateau was considered if three or more consecutive data points fell within a 5% response range. RESULTS: Thirty patients completed the study. There was a steady increase in the number of budesonide-treated patients exhibiting a maximal-response plateau on the dose-response curve from zero of 15 patients at run-in to nine of 14 patients at week 12, as compared with four of 16 patients in the placebo group (p = 0.03, chi square test). This was accompanied by a significant improvement in PC20 in the budesonide group as compared with the placebo group (p < 0.01 at week 12), whereas the changes in FEV1 were not significantly different between the groups (p = 0.77 at week 12). CONCLUSION: Regular treatment with the inhaled corticosteroid budesonide limits maximal airway narrowing in response to methacholine by introducing a plateau on the dose-response curve in patients with asthma, who were initially characterized by the absence of a plateau. This indicates that inhaled steroids are likely to reduce the hazard of unlimited airway narrowing in asthma. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/9058688/Protective_effect_of_inhaled_budesonide_against_unlimited_airway_narrowing_to_methacholine_in_atopic_patients_with_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(97)70050-2 DB - PRIME DP - Unbound Medicine ER -