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Plasma free iron: a possible cause of oedema in kwashiorkor.
Arch Dis Child 1997; 76(1):54-6AD

Abstract

BACKGROUND

Oedema is a sine qua non for the diagnosis of kwashiorkor yet the mechanisms leading to oedema remain ill defined.

AIMS

To relate the plasma concentration of radical promoting 'free' iron to the degree of oedema in patients with kwashiorkor.

SETTING

University teaching hospital.

PATIENTS

Fifteen children with kwashiorkor, nine of whom had severe and six of whom had a moderate degree of oedema.

METHODS

Plasma 'free' iron was measured as bleomycin detectable iron (BDI) and related to severity of oedema and plasma albumin concentration.

RESULTS

BDI was significantly higher in the patients with severe oedema (20.5 v 6.75 mumol/l) whereas the albumin concentrations were similar (16 v 17 g/l). BDI was no longer present in any patients 30 days after admission.

CONCLUSIONS

'Free' circulating iron may contribute to the oedema of kwashiorkor, and its sequestration could hasten recovery and decrease morbidity and mortality.

Authors+Show Affiliations

Department of Paediatrics and Child Health, University of Cape Town, Rondebosch, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9059163

Citation

Sive, A A., et al. "Plasma Free Iron: a Possible Cause of Oedema in Kwashiorkor." Archives of Disease in Childhood, vol. 76, no. 1, 1997, pp. 54-6.
Sive AA, Dempster WS, Malan H, et al. Plasma free iron: a possible cause of oedema in kwashiorkor. Arch Dis Child. 1997;76(1):54-6.
Sive, A. A., Dempster, W. S., Malan, H., Rosseau, S., & Heese, H. D. (1997). Plasma free iron: a possible cause of oedema in kwashiorkor. Archives of Disease in Childhood, 76(1), pp. 54-6.
Sive AA, et al. Plasma Free Iron: a Possible Cause of Oedema in Kwashiorkor. Arch Dis Child. 1997;76(1):54-6. PubMed PMID: 9059163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma free iron: a possible cause of oedema in kwashiorkor. AU - Sive,A A, AU - Dempster,W S, AU - Malan,H, AU - Rosseau,S, AU - Heese,H D, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 54 EP - 6 JF - Archives of disease in childhood JO - Arch. Dis. Child. VL - 76 IS - 1 N2 - BACKGROUND: Oedema is a sine qua non for the diagnosis of kwashiorkor yet the mechanisms leading to oedema remain ill defined. AIMS: To relate the plasma concentration of radical promoting 'free' iron to the degree of oedema in patients with kwashiorkor. SETTING: University teaching hospital. PATIENTS: Fifteen children with kwashiorkor, nine of whom had severe and six of whom had a moderate degree of oedema. METHODS: Plasma 'free' iron was measured as bleomycin detectable iron (BDI) and related to severity of oedema and plasma albumin concentration. RESULTS: BDI was significantly higher in the patients with severe oedema (20.5 v 6.75 mumol/l) whereas the albumin concentrations were similar (16 v 17 g/l). BDI was no longer present in any patients 30 days after admission. CONCLUSIONS: 'Free' circulating iron may contribute to the oedema of kwashiorkor, and its sequestration could hasten recovery and decrease morbidity and mortality. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/9059163/full_citation L2 - http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9059163 DB - PRIME DP - Unbound Medicine ER -