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Sucralfate prophylaxis of fluorouracil-induced stomatitis.
Tumori 1996 Nov-Dec; 82(6):585-7T

Abstract

AIMS AND BACKGROUND

Various attempts have been made to prevent 5-fluorouracil-induced stomatitis, with unsatisfactory results. Sucralfate is an aluminum hydroxide complex of sulfated sucrose commonly used in the treatment of gastroduodenal ulcers. We used the compound in a phase II study to reduce and minimize the stomatotoxicity of 5-fluorouracil chemotherapy administered in a multiple-day schedule.

METHODS

Fifty-two patients entered the study, and 129 cycles of chemotherapy were evaluated. Seven patients refused sucralfate rinses for taste intolerance.

RESULTS

A low level of stomatotoxicity was recorded: grade 2 stomatitis was observed after 14 cycles (10.8%) and grade 3 after 3 cycles (2.3%).

CONCLUSIONS

Sucralfate administration could have a role in the prevention of 5-fluorouracil-induced stomatitis.

Authors+Show Affiliations

Oncology Unit, Ospedale Madonna del Soccorso, San Benedetto del Tronto, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Clinical Trial, Phase II
Journal Article

Language

eng

PubMed ID

9061069

Citation

Giorgi, F, et al. "Sucralfate Prophylaxis of Fluorouracil-induced Stomatitis." Tumori, vol. 82, no. 6, 1996, pp. 585-7.
Giorgi F, Bascioni R, De Signoribus G, et al. Sucralfate prophylaxis of fluorouracil-induced stomatitis. Tumori. 1996;82(6):585-7.
Giorgi, F., Bascioni, R., De Signoribus, G., & Di Saverio, F. (1996). Sucralfate prophylaxis of fluorouracil-induced stomatitis. Tumori, 82(6), pp. 585-7.
Giorgi F, et al. Sucralfate Prophylaxis of Fluorouracil-induced Stomatitis. Tumori. 1996;82(6):585-7. PubMed PMID: 9061069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sucralfate prophylaxis of fluorouracil-induced stomatitis. AU - Giorgi,F, AU - Bascioni,R, AU - De Signoribus,G, AU - Di Saverio,F, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 585 EP - 7 JF - Tumori JO - Tumori VL - 82 IS - 6 N2 - AIMS AND BACKGROUND: Various attempts have been made to prevent 5-fluorouracil-induced stomatitis, with unsatisfactory results. Sucralfate is an aluminum hydroxide complex of sulfated sucrose commonly used in the treatment of gastroduodenal ulcers. We used the compound in a phase II study to reduce and minimize the stomatotoxicity of 5-fluorouracil chemotherapy administered in a multiple-day schedule. METHODS: Fifty-two patients entered the study, and 129 cycles of chemotherapy were evaluated. Seven patients refused sucralfate rinses for taste intolerance. RESULTS: A low level of stomatotoxicity was recorded: grade 2 stomatitis was observed after 14 cycles (10.8%) and grade 3 after 3 cycles (2.3%). CONCLUSIONS: Sucralfate administration could have a role in the prevention of 5-fluorouracil-induced stomatitis. SN - 0300-8916 UR - https://www.unboundmedicine.com/medline/citation/9061069/Sucralfate_prophylaxis_of_fluorouracil_induced_stomatitis_ DB - PRIME DP - Unbound Medicine ER -