Tags

Type your tag names separated by a space and hit enter

Low-density lipoprotein metabolism and its association to plasma lipoprotein(a) in the nephrotic syndrome.
Eur J Clin Invest. 1997 Feb; 27(2):169-77.EJ

Abstract

Patients with nephrotic syndrome have multiple abnormalities of lipoprotein metabolism, but the cause and exact nature of these abnormalities have not been established. In the present study we have determined the kinetics of plasma low-density lipoprotein (LDL) apoB in seven nephrotic patients demonstrating an elevated LDL apoB production rate (25.7 +/- 6.4 vs. 13.1 +/- 0.3 mgkg-1 day-1; P < 0.001) but a normal LDL apoB fractional catabolic rate (FCR) (0.31 +/- 0.04 vs. 0.33 +/- 0.008 pools day-1; NS) compared with 41 healthy control subjects. However, two out of the seven patients had a markedly low LDL apoB-FCR. Serum albumin was inversely correlated with the LDL apoB production rate (R = -0.82; P < 0.05). Plasma lipoprotein (a) [Lp(a)] levels were significantly (P < 0.001) increased in the nephrotic patients compared with control subjects. Significant correlations were observed between log Lp(a) and LDL apoB production rate (R = 0.90; P < 0.01), VLDL-cholesterol (R = 0.95; P < 0.001) and VLDL-triglycerides (R = 0.80; P < 0.05) respectively. In summary, the present study suggests that nephrotic hyperlipidaemia may be caused by at least two independent mechanisms. The elevated LDL apoB production rate is highly correlated with the prevailing levels of serum albumin, whereas some nephrotic patients seem to have a decreased LDL apoB clearance, suggesting impaired LDL receptor-mediated clearance. The present results also suggest that the elevated plasma Lp(a) levels in nephrosis are related to an increased hepatic synthesis rather than a decreased catabolism of lipoproteins.

Authors+Show Affiliations

Department of Renal Medicine, Karolinska Institute at Huddinge University Hospital, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9061312

Citation

Stenvinkel, P, et al. "Low-density Lipoprotein Metabolism and Its Association to Plasma Lipoprotein(a) in the Nephrotic Syndrome." European Journal of Clinical Investigation, vol. 27, no. 2, 1997, pp. 169-77.
Stenvinkel P, Berglund L, Ericsson S, et al. Low-density lipoprotein metabolism and its association to plasma lipoprotein(a) in the nephrotic syndrome. Eur J Clin Invest. 1997;27(2):169-77.
Stenvinkel, P., Berglund, L., Ericsson, S., Alvestrand, A., Angelin, B., & Eriksson, M. (1997). Low-density lipoprotein metabolism and its association to plasma lipoprotein(a) in the nephrotic syndrome. European Journal of Clinical Investigation, 27(2), 169-77.
Stenvinkel P, et al. Low-density Lipoprotein Metabolism and Its Association to Plasma Lipoprotein(a) in the Nephrotic Syndrome. Eur J Clin Invest. 1997;27(2):169-77. PubMed PMID: 9061312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-density lipoprotein metabolism and its association to plasma lipoprotein(a) in the nephrotic syndrome. AU - Stenvinkel,P, AU - Berglund,L, AU - Ericsson,S, AU - Alvestrand,A, AU - Angelin,B, AU - Eriksson,M, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 169 EP - 77 JF - European journal of clinical investigation JO - Eur. J. Clin. Invest. VL - 27 IS - 2 N2 - Patients with nephrotic syndrome have multiple abnormalities of lipoprotein metabolism, but the cause and exact nature of these abnormalities have not been established. In the present study we have determined the kinetics of plasma low-density lipoprotein (LDL) apoB in seven nephrotic patients demonstrating an elevated LDL apoB production rate (25.7 +/- 6.4 vs. 13.1 +/- 0.3 mgkg-1 day-1; P < 0.001) but a normal LDL apoB fractional catabolic rate (FCR) (0.31 +/- 0.04 vs. 0.33 +/- 0.008 pools day-1; NS) compared with 41 healthy control subjects. However, two out of the seven patients had a markedly low LDL apoB-FCR. Serum albumin was inversely correlated with the LDL apoB production rate (R = -0.82; P < 0.05). Plasma lipoprotein (a) [Lp(a)] levels were significantly (P < 0.001) increased in the nephrotic patients compared with control subjects. Significant correlations were observed between log Lp(a) and LDL apoB production rate (R = 0.90; P < 0.01), VLDL-cholesterol (R = 0.95; P < 0.001) and VLDL-triglycerides (R = 0.80; P < 0.05) respectively. In summary, the present study suggests that nephrotic hyperlipidaemia may be caused by at least two independent mechanisms. The elevated LDL apoB production rate is highly correlated with the prevailing levels of serum albumin, whereas some nephrotic patients seem to have a decreased LDL apoB clearance, suggesting impaired LDL receptor-mediated clearance. The present results also suggest that the elevated plasma Lp(a) levels in nephrosis are related to an increased hepatic synthesis rather than a decreased catabolism of lipoproteins. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/9061312/Low_density_lipoprotein_metabolism_and_its_association_to_plasma_lipoprotein_a__in_the_nephrotic_syndrome_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0014-2972&amp;date=1997&amp;volume=27&amp;issue=2&amp;spage=169 DB - PRIME DP - Unbound Medicine ER -