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[Recurrence of hepatitis caused by hepatitis c virus in patients receiving a liver transplant].
Med Clin (Barc). 1997 Jan 25; 108(3):98-102.MC

Abstract

BACKGROUND

Liver disease due to hepatitis C virus (HCV) is an increasingly frequent indication for liver transplantation. We performed a clinical and virological study of 20 HCV-infected liver transplant recipients to correlate virological markers with histological recurrence of disease.

PATIENTS AND METHODS

In ninety-four patients who were given transplants for end-stage cirrhosis, IgG and IgM antibodies to HCV and IgM to HCV tested by ELISA; all samples were further examined in a four-antigen recombinant immunoblot assay (2-RIBA). HCV viremia was measured by the conventional nested PCR, HCV genotype was determined by PCR amplification using type-specific primers. We have analyzed de novo infection by HCV, HCV recurrence and the influence of genotype in these recurrence.

RESULTS

Nineteen of 20 antibody-positive patients (95%) had HCV RNA before transplantation. All 19 patients who were viremic before transplantation had persistent infection after LT. HCV genotype 1b was the predominant type before and after LT (75%). Ten of the 20 (50%) patients developed histological findings of chronic hepatitis (CH) in liver allografts. HCV recurrent liver disease after LT was not related with HCV genotype. Of 4 deaths after transplant in hepatitis C group, only one was related to recurrent disease. We have not found de novo hepatitis C.

CONCLUSIONS

Our results indicate the general persistence of hepatitis C virus infection and the excellent short-term prognosis after liver transplantation. Chronic hepatitis by HCV in liver transplant was not related with HCV genotype.

Authors+Show Affiliations

Servicio de Aparato Digestivo, Hospital Universitario Marqués de Valdecilla, Facultad de Medicina, Santander.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

9064439

Citation

Crespo, J, et al. "[Recurrence of Hepatitis Caused By Hepatitis C Virus in Patients Receiving a Liver Transplant]." Medicina Clinica, vol. 108, no. 3, 1997, pp. 98-102.
Crespo J, Casafont F, Carte B, et al. [Recurrence of hepatitis caused by hepatitis c virus in patients receiving a liver transplant]. Med Clin (Barc). 1997;108(3):98-102.
Crespo, J., Casafont, F., Carte, B., Lozano, J. L., Fábrega, E., Sánchez-Antolín, G., Dueñas, C., & Pons Romero, F. (1997). [Recurrence of hepatitis caused by hepatitis c virus in patients receiving a liver transplant]. Medicina Clinica, 108(3), 98-102.
Crespo J, et al. [Recurrence of Hepatitis Caused By Hepatitis C Virus in Patients Receiving a Liver Transplant]. Med Clin (Barc). 1997 Jan 25;108(3):98-102. PubMed PMID: 9064439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Recurrence of hepatitis caused by hepatitis c virus in patients receiving a liver transplant]. AU - Crespo,J, AU - Casafont,F, AU - Carte,B, AU - Lozano,J L, AU - Fábrega,E, AU - Sánchez-Antolín,G, AU - Dueñas,C, AU - Pons Romero,F, PY - 1997/1/25/pubmed PY - 1997/1/25/medline PY - 1997/1/25/entrez SP - 98 EP - 102 JF - Medicina clinica JO - Med Clin (Barc) VL - 108 IS - 3 N2 - BACKGROUND: Liver disease due to hepatitis C virus (HCV) is an increasingly frequent indication for liver transplantation. We performed a clinical and virological study of 20 HCV-infected liver transplant recipients to correlate virological markers with histological recurrence of disease. PATIENTS AND METHODS: In ninety-four patients who were given transplants for end-stage cirrhosis, IgG and IgM antibodies to HCV and IgM to HCV tested by ELISA; all samples were further examined in a four-antigen recombinant immunoblot assay (2-RIBA). HCV viremia was measured by the conventional nested PCR, HCV genotype was determined by PCR amplification using type-specific primers. We have analyzed de novo infection by HCV, HCV recurrence and the influence of genotype in these recurrence. RESULTS: Nineteen of 20 antibody-positive patients (95%) had HCV RNA before transplantation. All 19 patients who were viremic before transplantation had persistent infection after LT. HCV genotype 1b was the predominant type before and after LT (75%). Ten of the 20 (50%) patients developed histological findings of chronic hepatitis (CH) in liver allografts. HCV recurrent liver disease after LT was not related with HCV genotype. Of 4 deaths after transplant in hepatitis C group, only one was related to recurrent disease. We have not found de novo hepatitis C. CONCLUSIONS: Our results indicate the general persistence of hepatitis C virus infection and the excellent short-term prognosis after liver transplantation. Chronic hepatitis by HCV in liver transplant was not related with HCV genotype. SN - 0025-7753 UR - https://www.unboundmedicine.com/medline/citation/9064439/[Recurrence_of_hepatitis_caused_by_hepatitis_c_virus_in_patients_receiving_a_liver_transplant]_ L2 - http://www.diseaseinfosearch.org/result/4282 DB - PRIME DP - Unbound Medicine ER -