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Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques.
Ann Neurol 1997; 41(3):402-4AN

Abstract

Inheritance of the apolipoprotein E (ApoE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of beta-amyloid (A beta) in AD, Down's syndrome, and normal aging. A beta deposition in the form of senile plaques (SPs) has recently been described in patients with temporal lobe epilepsy (TLE). We studied the relationship between ApoE epsilon 4 genotype and the deposition of A beta in temporal lobe tissue from patients who underwent temporal lobectomy for intractable epilepsy. TLE patients with SPs had a 70% ApoE epsilon 4 carrier frequency compared with a 27% carrier frequency among age-matched TLE controls without SPs. Our data suggest that the association between ApoE epsilon 4 and intracerebral A beta accumulation is not unique to the elderly or to those with dementia, and may be a feature of conditions in which there is both an ApoE epsilon 4 allele and over-production of A beta precursor protein, and, presumably, A beta.

Authors+Show Affiliations

Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA. gkgouras@mail.med.cornell.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9066363

Citation

Gouras, G K., et al. "Increased Apolipoprotein E Epsilon 4 in Epilepsy With Senile Plaques." Annals of Neurology, vol. 41, no. 3, 1997, pp. 402-4.
Gouras GK, Relkin NR, Sweeney D, et al. Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. Ann Neurol. 1997;41(3):402-4.
Gouras, G. K., Relkin, N. R., Sweeney, D., Munoz, D. G., Mackenzie, I. R., & Gandy, S. (1997). Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. Annals of Neurology, 41(3), pp. 402-4.
Gouras GK, et al. Increased Apolipoprotein E Epsilon 4 in Epilepsy With Senile Plaques. Ann Neurol. 1997;41(3):402-4. PubMed PMID: 9066363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. AU - Gouras,G K, AU - Relkin,N R, AU - Sweeney,D, AU - Munoz,D G, AU - Mackenzie,I R, AU - Gandy,S, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 402 EP - 4 JF - Annals of neurology JO - Ann. Neurol. VL - 41 IS - 3 N2 - Inheritance of the apolipoprotein E (ApoE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of beta-amyloid (A beta) in AD, Down's syndrome, and normal aging. A beta deposition in the form of senile plaques (SPs) has recently been described in patients with temporal lobe epilepsy (TLE). We studied the relationship between ApoE epsilon 4 genotype and the deposition of A beta in temporal lobe tissue from patients who underwent temporal lobectomy for intractable epilepsy. TLE patients with SPs had a 70% ApoE epsilon 4 carrier frequency compared with a 27% carrier frequency among age-matched TLE controls without SPs. Our data suggest that the association between ApoE epsilon 4 and intracerebral A beta accumulation is not unique to the elderly or to those with dementia, and may be a feature of conditions in which there is both an ApoE epsilon 4 allele and over-production of A beta precursor protein, and, presumably, A beta. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/9066363/Increased_apolipoprotein_E_epsilon_4_in_epilepsy_with_senile_plaques_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1997&volume=41&issue=3&spage=402 DB - PRIME DP - Unbound Medicine ER -