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Contact hypersensitivity in patients with orofacial granulomatosis.
Am J Contact Dermat 1997; 8(1):35-8AJ

Abstract

BACKGROUND

Orofacial granulomatosis is a clinical entity presenting with chronic swelling of the oral or facial tissues in association with histological evidence of noncaseating granulomatous inflammation. Its cause remains unclear, but a possible role of contact sensitivity to dietary components has been proposed.

OBJECTIVES

This study was performed to document the prevalence of contact sensitivity to food additives in patients with orofacial granulomatosis and assess the role of elimination diets in management.

METHODS

Successive patients with a clinical diagnosis of orofacial granulomatosis were patch tested to the European Standard series and an Oral Battery containing common food additives. In addition, testing for immediate contact reactions to components of the Oral Battery was performed. In selected cases, appropriate elimination diets were implemented.

RESULTS

Forty-eight patients were investigated. Ten showed positive reactions to components of the Oral Battery on standard patch testing and, of these, seven showed improvement on an elimination diet.

CONCLUSIONS

Orofacial granulomatosis is a heterogenous clinical entity. Patch testing permits identification of a subgroup of patients likely to benefit from dietary manipulation and allows more appropriate targeting of such treatment.

Authors+Show Affiliations

Department of Dermatology, Royal Group of Hospitals, Belfast, Northern Ireland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9066847

Citation

Armstrong, D K., et al. "Contact Hypersensitivity in Patients With Orofacial Granulomatosis." American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, vol. 8, no. 1, 1997, pp. 35-8.
Armstrong DK, Biagioni P, Lamey PJ, et al. Contact hypersensitivity in patients with orofacial granulomatosis. Am J Contact Dermatitis. 1997;8(1):35-8.
Armstrong, D. K., Biagioni, P., Lamey, P. J., & Burrows, D. (1997). Contact hypersensitivity in patients with orofacial granulomatosis. American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 8(1), pp. 35-8.
Armstrong DK, et al. Contact Hypersensitivity in Patients With Orofacial Granulomatosis. Am J Contact Dermatitis. 1997;8(1):35-8. PubMed PMID: 9066847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contact hypersensitivity in patients with orofacial granulomatosis. AU - Armstrong,D K, AU - Biagioni,P, AU - Lamey,P J, AU - Burrows,D, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 35 EP - 8 JF - American journal of contact dermatitis : official journal of the American Contact Dermatitis Society JO - Am. J. Contact Dermatitis VL - 8 IS - 1 N2 - BACKGROUND: Orofacial granulomatosis is a clinical entity presenting with chronic swelling of the oral or facial tissues in association with histological evidence of noncaseating granulomatous inflammation. Its cause remains unclear, but a possible role of contact sensitivity to dietary components has been proposed. OBJECTIVES: This study was performed to document the prevalence of contact sensitivity to food additives in patients with orofacial granulomatosis and assess the role of elimination diets in management. METHODS: Successive patients with a clinical diagnosis of orofacial granulomatosis were patch tested to the European Standard series and an Oral Battery containing common food additives. In addition, testing for immediate contact reactions to components of the Oral Battery was performed. In selected cases, appropriate elimination diets were implemented. RESULTS: Forty-eight patients were investigated. Ten showed positive reactions to components of the Oral Battery on standard patch testing and, of these, seven showed improvement on an elimination diet. CONCLUSIONS: Orofacial granulomatosis is a heterogenous clinical entity. Patch testing permits identification of a subgroup of patients likely to benefit from dietary manipulation and allows more appropriate targeting of such treatment. SN - 1046-199X UR - https://www.unboundmedicine.com/medline/citation/9066847/Contact_hypersensitivity_in_patients_with_orofacial_granulomatosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1046199X97000080 DB - PRIME DP - Unbound Medicine ER -