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Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene.
Cancer Res. 1997 Mar 15; 57(6):1039-42.CR

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromosome 11q13.

Authors+Show Affiliations

Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9067266

Citation

Debelenko, L V., et al. "Haplotype Analysis Defines a Minimal Interval for the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene." Cancer Research, vol. 57, no. 6, 1997, pp. 1039-42.
Debelenko LV, Emmert-Buck MR, Manickam P, et al. Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Res. 1997;57(6):1039-42.
Debelenko, L. V., Emmert-Buck, M. R., Manickam, P., Kester, M., Guru, S. C., DiFranco, E. M., Olufemi, S. E., Agarwal, S., Lubensky, I. A., Zhuang, Z., Burns, A. L., Spiegel, A. M., Liotta, L. A., Collins, F. S., Marx, S. J., & Chandrasekharappa, S. C. (1997). Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Research, 57(6), 1039-42.
Debelenko LV, et al. Haplotype Analysis Defines a Minimal Interval for the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene. Cancer Res. 1997 Mar 15;57(6):1039-42. PubMed PMID: 9067266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. AU - Debelenko,L V, AU - Emmert-Buck,M R, AU - Manickam,P, AU - Kester,M, AU - Guru,S C, AU - DiFranco,E M, AU - Olufemi,S E, AU - Agarwal,S, AU - Lubensky,I A, AU - Zhuang,Z, AU - Burns,A L, AU - Spiegel,A M, AU - Liotta,L A, AU - Collins,F S, AU - Marx,S J, AU - Chandrasekharappa,S C, PY - 1997/3/15/pubmed PY - 1997/3/15/medline PY - 1997/3/15/entrez SP - 1039 EP - 42 JF - Cancer research JO - Cancer Res VL - 57 IS - 6 N2 - Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromosome 11q13. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9067266/Haplotype_analysis_defines_a_minimal_interval_for_the_multiple_endocrine_neoplasia_type_1__MEN1__gene_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9067266 DB - PRIME DP - Unbound Medicine ER -