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Lansoprazole heals erosive reflux esophagitis resistant to histamine H2-receptor antagonist therapy.
Am J Gastroenterol. 1997 Mar; 92(3):429-37.AJ

Abstract

PURPOSE

We conducted a randomized, double-blind, multicenter clinical trial to determine whether lansoprazole was superior to continued therapy with histamine H2-receptor antagonist therapy in healing erosive reflux esophagitis.

METHODS

Investigators from nine medical centers enrolled 159 patients with endoscopically documented esophageal erosions and/or ulcers that had failed to heal with 12 or more wk of at least standard dosages of histamine H2-receptor antagonist therapy. Patients received ranitidine 150 mg b.i.d. for 8 wk or lansoprazole 30 mg for 4 wk followed by either lansoprazole 30 mg or lansoprazole 60 mg for another 4 wk of treatment. Patients underwent endoscopy at screening and at weeks 2, 4, and 8.

RESULTS

At 2, 4, and 8 wk of therapy, healing rates were significantly higher in the lansoprazole group compared with the ranitidine group (p < 0.001). By 8 wk, 84% of the lansoprazole group were healed as opposed to only 32% of the ranitidine group. Lansoprazole was superior to ranitidine in providing relief of upper abdominal burning and daytime heartburn (p < 0.001) and reducing the need for antacids (p < 0.001). Lansoprazole patients had less interference with sleep and less day time drowsiness than ranitidine patients (p = 0.05). The percentages of patients with adverse events were similar in both groups. Fasting serum gastrin levels at weeks 4 and 8 were significantly higher in the lansoprazole group compared with the ranitidine group.

CONCLUSION

Eight weeks of lansoprazole therapy is safe, superior to continued ranitidine therapy, and effective in healing more than 80% of patients with erosive reflux esophagitis previously resistant to histamine H2-receptor antagonist therapy.

Authors+Show Affiliations

Department of Medicine, Veterans Affairs Hospital, Hines, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9068463

Citation

Sontag, S J., et al. "Lansoprazole Heals Erosive Reflux Esophagitis Resistant to Histamine H2-receptor Antagonist Therapy." The American Journal of Gastroenterology, vol. 92, no. 3, 1997, pp. 429-37.
Sontag SJ, Kogut DG, Fleischmann R, et al. Lansoprazole heals erosive reflux esophagitis resistant to histamine H2-receptor antagonist therapy. Am J Gastroenterol. 1997;92(3):429-37.
Sontag, S. J., Kogut, D. G., Fleischmann, R., Campbell, D. R., Richter, J., Robinson, M., McFarland, M., Sabesin, S., Lehman, G. A., & Castell, D. (1997). Lansoprazole heals erosive reflux esophagitis resistant to histamine H2-receptor antagonist therapy. The American Journal of Gastroenterology, 92(3), 429-37.
Sontag SJ, et al. Lansoprazole Heals Erosive Reflux Esophagitis Resistant to Histamine H2-receptor Antagonist Therapy. Am J Gastroenterol. 1997;92(3):429-37. PubMed PMID: 9068463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lansoprazole heals erosive reflux esophagitis resistant to histamine H2-receptor antagonist therapy. AU - Sontag,S J, AU - Kogut,D G, AU - Fleischmann,R, AU - Campbell,D R, AU - Richter,J, AU - Robinson,M, AU - McFarland,M, AU - Sabesin,S, AU - Lehman,G A, AU - Castell,D, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 429 EP - 37 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 92 IS - 3 N2 - PURPOSE: We conducted a randomized, double-blind, multicenter clinical trial to determine whether lansoprazole was superior to continued therapy with histamine H2-receptor antagonist therapy in healing erosive reflux esophagitis. METHODS: Investigators from nine medical centers enrolled 159 patients with endoscopically documented esophageal erosions and/or ulcers that had failed to heal with 12 or more wk of at least standard dosages of histamine H2-receptor antagonist therapy. Patients received ranitidine 150 mg b.i.d. for 8 wk or lansoprazole 30 mg for 4 wk followed by either lansoprazole 30 mg or lansoprazole 60 mg for another 4 wk of treatment. Patients underwent endoscopy at screening and at weeks 2, 4, and 8. RESULTS: At 2, 4, and 8 wk of therapy, healing rates were significantly higher in the lansoprazole group compared with the ranitidine group (p < 0.001). By 8 wk, 84% of the lansoprazole group were healed as opposed to only 32% of the ranitidine group. Lansoprazole was superior to ranitidine in providing relief of upper abdominal burning and daytime heartburn (p < 0.001) and reducing the need for antacids (p < 0.001). Lansoprazole patients had less interference with sleep and less day time drowsiness than ranitidine patients (p = 0.05). The percentages of patients with adverse events were similar in both groups. Fasting serum gastrin levels at weeks 4 and 8 were significantly higher in the lansoprazole group compared with the ranitidine group. CONCLUSION: Eight weeks of lansoprazole therapy is safe, superior to continued ranitidine therapy, and effective in healing more than 80% of patients with erosive reflux esophagitis previously resistant to histamine H2-receptor antagonist therapy. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9068463/Lansoprazole_heals_erosive_reflux_esophagitis_resistant_to_histamine_H2_receptor_antagonist_therapy_ L2 - https://www.lens.org/lens/search?q=citation_id:9068463 DB - PRIME DP - Unbound Medicine ER -