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Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors.
J Psychiatry Neurosci. 1997 Mar; 22(2):127-31.JP

Abstract

The importance of continuation and maintenance antidepressant therapy has been increasingly recognized, but usually focuses on tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants. This review examines the evidence in support of classical monoamine oxidase inhibitor (MAOI) agents and the selective reversible monoamine oxidase type A inhibitor moclobemide in continuation and maintenance therapy. Phenelzine and tranylcypromine have demonstrated long-term efficacy but often cause intolerable side effects. Moclobemide is a well-tolerated alternative antidepressant, but there is a need for prospective controlled trials to evaluate its long-term efficacy.

Authors+Show Affiliations

Department of Psychiatry, University of Toronto, Ontario, Canada.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

9074307

Citation

Kennedy, S H.. "Continuation and Maintenance Treatments in Major Depression: the Neglected Role of Monoamine Oxidase Inhibitors." Journal of Psychiatry & Neuroscience : JPN, vol. 22, no. 2, 1997, pp. 127-31.
Kennedy SH. Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors. J Psychiatry Neurosci. 1997;22(2):127-31.
Kennedy, S. H. (1997). Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors. Journal of Psychiatry & Neuroscience : JPN, 22(2), 127-31.
Kennedy SH. Continuation and Maintenance Treatments in Major Depression: the Neglected Role of Monoamine Oxidase Inhibitors. J Psychiatry Neurosci. 1997;22(2):127-31. PubMed PMID: 9074307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors. A1 - Kennedy,S H, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 127 EP - 31 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 22 IS - 2 N2 - The importance of continuation and maintenance antidepressant therapy has been increasingly recognized, but usually focuses on tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants. This review examines the evidence in support of classical monoamine oxidase inhibitor (MAOI) agents and the selective reversible monoamine oxidase type A inhibitor moclobemide in continuation and maintenance therapy. Phenelzine and tranylcypromine have demonstrated long-term efficacy but often cause intolerable side effects. Moclobemide is a well-tolerated alternative antidepressant, but there is a need for prospective controlled trials to evaluate its long-term efficacy. SN - 1180-4882 UR - https://www.unboundmedicine.com/medline/citation/9074307/Continuation_and_maintenance_treatments_in_major_depression:_the_neglected_role_of_monoamine_oxidase_inhibitors_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9074307/ DB - PRIME DP - Unbound Medicine ER -