Tags

Type your tag names separated by a space and hit enter

Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage.
Neurobiol Learn Mem. 1997 Mar; 67(2):176-9.NL

Abstract

The present study examined the effects, in male Sprague-Dawley rats, or microinfusion of drugs affecting glucocorticoid receptors (GRs or Type II) administered into either the basolateral (BLA) or central nucleus of the amygdala (CEA) on memory for training in an inhibitory avoidance and water-maze escape task. The specific GR agonist RU 28362 (1.0 or 3.0 ng) infused into the BLA immediately after training in a one-trial inhibitory avoidance task dose-dependently enhanced 48-h retention, whereas infusion of the GR agonist into the CEA did not affect retention. Additionally, pretraining microinfusions of the specific GR antagonist RU 38486 (0.3, 1.0, or 3.0 ng) into the BLA, but not infusions into the CEA, impaired memory for escape training to find a submerged platform in a water maze. These findings indicate that glucocorticoids affect memory storage, at least in part, by binding directly to GRs in the BLA and provide further evidence for the view that the BLA is an important brain region in integrating hormonal and neurotransmitter influences on memory storage.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697-3800, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9075247

Citation

Roozendaal, B, and J L. McGaugh. "Glucocorticoid Receptor Agonist and Antagonist Administration Into the Basolateral but Not Central Amygdala Modulates Memory Storage." Neurobiology of Learning and Memory, vol. 67, no. 2, 1997, pp. 176-9.
Roozendaal B, McGaugh JL. Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiol Learn Mem. 1997;67(2):176-9.
Roozendaal, B., & McGaugh, J. L. (1997). Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiology of Learning and Memory, 67(2), 176-9.
Roozendaal B, McGaugh JL. Glucocorticoid Receptor Agonist and Antagonist Administration Into the Basolateral but Not Central Amygdala Modulates Memory Storage. Neurobiol Learn Mem. 1997;67(2):176-9. PubMed PMID: 9075247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. AU - Roozendaal,B, AU - McGaugh,J L, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 176 EP - 9 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 67 IS - 2 N2 - The present study examined the effects, in male Sprague-Dawley rats, or microinfusion of drugs affecting glucocorticoid receptors (GRs or Type II) administered into either the basolateral (BLA) or central nucleus of the amygdala (CEA) on memory for training in an inhibitory avoidance and water-maze escape task. The specific GR agonist RU 28362 (1.0 or 3.0 ng) infused into the BLA immediately after training in a one-trial inhibitory avoidance task dose-dependently enhanced 48-h retention, whereas infusion of the GR agonist into the CEA did not affect retention. Additionally, pretraining microinfusions of the specific GR antagonist RU 38486 (0.3, 1.0, or 3.0 ng) into the BLA, but not infusions into the CEA, impaired memory for escape training to find a submerged platform in a water maze. These findings indicate that glucocorticoids affect memory storage, at least in part, by binding directly to GRs in the BLA and provide further evidence for the view that the BLA is an important brain region in integrating hormonal and neurotransmitter influences on memory storage. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/9075247/Glucocorticoid_receptor_agonist_and_antagonist_administration_into_the_basolateral_but_not_central_amygdala_modulates_memory_storage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(96)93765-X DB - PRIME DP - Unbound Medicine ER -