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Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
J Clin Invest 1997; 99(6):1287-94JCI

Abstract

High calcium intake during childhood has been suggested to increase bone mass accrual, potentially resulting in a greater peak bone mass. Whether the effects of calcium supplementation on bone mass accrual vary from one skeletal region to another, and to what extent the level of spontaneous calcium intake may affect the magnitude of the response has, however, not yet been clearly established. In a double-blind, placebo-controlled study, 149 healthy prepubertal girls aged 7.9+/-0.1 yr (mean+/-SEM) were either allocated two food products containing 850 mg of calcium (Ca-suppl.) or not (placebo) on a daily basis for 1 yr. Areal bone mineral density (BMD), bone mineral content (BMC), and bone size were determined at six sites by dual-energy x-ray absorptiometry. The difference in BMD gain between calcium-supplemented (Ca-suppl.) and placebo was greater at radial (metaphysis and diaphysis) and femoral (neck, trochanter, and diaphyses) sites (7-12 mg/cm2 per yr) than in the lumbar spine (2 mg/cm2 per yr). The difference in BMD gains between Ca-suppl. and placebo was greatest in girls with a spontaneous calcium intake below the median of 880 mg/d. The increase in mean BMD of the 6 sites in the low-calcium consumers was accompanied by increased gains in mean BMC, bone size, and statural height. These results suggest a possible positive effect of calcium supplementation on skeletal growth at that age. In conclusion, calcium-enriched foods significantly increased bone mass accrual in prepubertal girls, with a preferential effect in the appendicular skeleton, and greater benefit at lower spontaneous calcium intake.

Authors+Show Affiliations

Division of Bone Diseases, WHO Collaborating Center for Osteoporosis and Bone Disease, Geneva, Switzerland.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9077538

Citation

Bonjour, J P., et al. "Calcium-enriched Foods and Bone Mass Growth in Prepubertal Girls: a Randomized, Double-blind, Placebo-controlled Trial." The Journal of Clinical Investigation, vol. 99, no. 6, 1997, pp. 1287-94.
Bonjour JP, Carrie AL, Ferrari S, et al. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. J Clin Invest. 1997;99(6):1287-94.
Bonjour, J. P., Carrie, A. L., Ferrari, S., Clavien, H., Slosman, D., Theintz, G., & Rizzoli, R. (1997). Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. The Journal of Clinical Investigation, 99(6), pp. 1287-94.
Bonjour JP, et al. Calcium-enriched Foods and Bone Mass Growth in Prepubertal Girls: a Randomized, Double-blind, Placebo-controlled Trial. J Clin Invest. 1997 Mar 15;99(6):1287-94. PubMed PMID: 9077538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. AU - Bonjour,J P, AU - Carrie,A L, AU - Ferrari,S, AU - Clavien,H, AU - Slosman,D, AU - Theintz,G, AU - Rizzoli,R, PY - 1997/3/15/pubmed PY - 1997/3/15/medline PY - 1997/3/15/entrez SP - 1287 EP - 94 JF - The Journal of clinical investigation JO - J. Clin. Invest. VL - 99 IS - 6 N2 - High calcium intake during childhood has been suggested to increase bone mass accrual, potentially resulting in a greater peak bone mass. Whether the effects of calcium supplementation on bone mass accrual vary from one skeletal region to another, and to what extent the level of spontaneous calcium intake may affect the magnitude of the response has, however, not yet been clearly established. In a double-blind, placebo-controlled study, 149 healthy prepubertal girls aged 7.9+/-0.1 yr (mean+/-SEM) were either allocated two food products containing 850 mg of calcium (Ca-suppl.) or not (placebo) on a daily basis for 1 yr. Areal bone mineral density (BMD), bone mineral content (BMC), and bone size were determined at six sites by dual-energy x-ray absorptiometry. The difference in BMD gain between calcium-supplemented (Ca-suppl.) and placebo was greater at radial (metaphysis and diaphysis) and femoral (neck, trochanter, and diaphyses) sites (7-12 mg/cm2 per yr) than in the lumbar spine (2 mg/cm2 per yr). The difference in BMD gains between Ca-suppl. and placebo was greatest in girls with a spontaneous calcium intake below the median of 880 mg/d. The increase in mean BMD of the 6 sites in the low-calcium consumers was accompanied by increased gains in mean BMC, bone size, and statural height. These results suggest a possible positive effect of calcium supplementation on skeletal growth at that age. In conclusion, calcium-enriched foods significantly increased bone mass accrual in prepubertal girls, with a preferential effect in the appendicular skeleton, and greater benefit at lower spontaneous calcium intake. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/9077538/Calcium_enriched_foods_and_bone_mass_growth_in_prepubertal_girls:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://doi.org/10.1172/JCI119287 DB - PRIME DP - Unbound Medicine ER -