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[Enhanced lymphocyte proliferative response to house dust mite in infants with atopic dermatitis].
Arerugi. 1997 Jan; 46(1):34-41.A

Abstract

Allergen-specific lymphocyte proliferation was measured in 24 children with atopic dermatitis and 20 non-atopic controls. The level of house dust mite-specific S.I.F. (stimulation index measured by flow cytometry) in the atopic children was significantly higher than that in the non-atopic controls in every age-group, suggesting that the elevation of the mite-specific S.I.F. level is related to the development of atopic dermatitis. The level of house dust mite-specific S.I.F. correlated significantly with the level of house dust mite-specific IgE-RAST in older children (r < 0.73, p < 0.001), indicating that S.I.F. reflects the activity of lymphocytes competent to promote the production of IgE. In the atopic infants, there was no significant positive correlation between the levels of mite-specific S.I.F. and mite-specific IgE-RAST since, although the former was usually elevated the latter was often very low or negative. The result suggests that the sensitization of T lymphocytes to house dust mite begins as early as in infancy prior to the development of mite-specific IgE antibody.

Authors+Show Affiliations

Kimura M
Division of Allergy, Clinical Immunology and Infectious Diseases, Shizuoka Children's Hospital.
Tsuruta S
No affiliation info available
Yoshida T
No affiliation info available

MeSH

AdolescentAnimalsChildChild, PreschoolDermatitis, AtopicDustHumansImmunoglobulin ELymphocyte ActivationMitesRadioallergosorbent Test

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

9078610

Citation

Kimura, M, et al. "[Enhanced Lymphocyte Proliferative Response to House Dust Mite in Infants With Atopic Dermatitis]." Arerugi = [Allergy], vol. 46, no. 1, 1997, pp. 34-41.
Kimura M, Tsuruta S, Yoshida T. [Enhanced lymphocyte proliferative response to house dust mite in infants with atopic dermatitis]. Arerugi. 1997;46(1):34-41.
Kimura, M., Tsuruta, S., & Yoshida, T. (1997). [Enhanced lymphocyte proliferative response to house dust mite in infants with atopic dermatitis]. Arerugi = [Allergy], 46(1), 34-41.
Kimura M, Tsuruta S, Yoshida T. [Enhanced Lymphocyte Proliferative Response to House Dust Mite in Infants With Atopic Dermatitis]. Arerugi. 1997;46(1):34-41. PubMed PMID: 9078610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Enhanced lymphocyte proliferative response to house dust mite in infants with atopic dermatitis]. AU - Kimura,M, AU - Tsuruta,S, AU - Yoshida,T, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 34 EP - 41 JF - Arerugi = [Allergy] JO - Arerugi VL - 46 IS - 1 N2 - Allergen-specific lymphocyte proliferation was measured in 24 children with atopic dermatitis and 20 non-atopic controls. The level of house dust mite-specific S.I.F. (stimulation index measured by flow cytometry) in the atopic children was significantly higher than that in the non-atopic controls in every age-group, suggesting that the elevation of the mite-specific S.I.F. level is related to the development of atopic dermatitis. The level of house dust mite-specific S.I.F. correlated significantly with the level of house dust mite-specific IgE-RAST in older children (r < 0.73, p < 0.001), indicating that S.I.F. reflects the activity of lymphocytes competent to promote the production of IgE. In the atopic infants, there was no significant positive correlation between the levels of mite-specific S.I.F. and mite-specific IgE-RAST since, although the former was usually elevated the latter was often very low or negative. The result suggests that the sensitization of T lymphocytes to house dust mite begins as early as in infancy prior to the development of mite-specific IgE antibody. SN - 0021-4884 UR - https://www.unboundmedicine.com/medline/citation/9078610/[Enhanced_lymphocyte_proliferative_response_to_house_dust_mite_in_infants_with_atopic_dermatitis]_ L2 - http://www.diseaseinfosearch.org/result/9652 DB - PRIME DP - Unbound Medicine ER -