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Adenoid lymphocyte responses to outer membrane protein P6 of nontypable Haemophilus influenzae in children with and without otitis media.
Acta Otolaryngol Suppl. 1996; 523:153-4.AO

Abstract

The cellular immune responses to nontypable Haemophilus influenzae in adenoids were determined in children by measuring lymphocyte blast transformation and antibody secretion in response to the P6 outer membrane protein. In the lymphocyte transformation assay, stimulation index of adenoid lymphocytes stimulated by P6 in otitis children (2.34 +/- 0.25) was significantly lower than that in non-otitis children (3.91 +/- 0.64, p <0.05). The number of IgM as well as IgA secreting cells after 8 days' culture with P6 were significantly smaller in otitis children (IgM: 7,534 +/- 2,843/10(6) lymphocyte; IgA: 1,573 +/- 620/10(6) lymphocyte) than those in non-otitis children (IgM: 12,994 +/- 2,533, p <0.05; IgA: 2,828 +/- 528, p <0.05). These data suggest that P6 protein is a target for the cellular immune response of the adenoid, and failure of adenoid lymphocytes to recognize it as a specific immunogen may be one of the causes of recurrent otitis media.

Authors+Show Affiliations

Department of Otolaryngology, Sapporo Medical University, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9082766

Citation

Kodama, H, et al. "Adenoid Lymphocyte Responses to Outer Membrane Protein P6 of Nontypable Haemophilus Influenzae in Children With and Without Otitis Media." Acta Oto-laryngologica. Supplementum, vol. 523, 1996, pp. 153-4.
Kodama H, Faden H, Harabuchi Y, et al. Adenoid lymphocyte responses to outer membrane protein P6 of nontypable Haemophilus influenzae in children with and without otitis media. Acta Otolaryngol Suppl. 1996;523:153-4.
Kodama, H., Faden, H., Harabuchi, Y., Kataura, A., Bernstein, J. M., & Brodsky, L. (1996). Adenoid lymphocyte responses to outer membrane protein P6 of nontypable Haemophilus influenzae in children with and without otitis media. Acta Oto-laryngologica. Supplementum, 523, 153-4.
Kodama H, et al. Adenoid Lymphocyte Responses to Outer Membrane Protein P6 of Nontypable Haemophilus Influenzae in Children With and Without Otitis Media. Acta Otolaryngol Suppl. 1996;523:153-4. PubMed PMID: 9082766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenoid lymphocyte responses to outer membrane protein P6 of nontypable Haemophilus influenzae in children with and without otitis media. AU - Kodama,H, AU - Faden,H, AU - Harabuchi,Y, AU - Kataura,A, AU - Bernstein,J M, AU - Brodsky,L, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 153 EP - 4 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl VL - 523 N2 - The cellular immune responses to nontypable Haemophilus influenzae in adenoids were determined in children by measuring lymphocyte blast transformation and antibody secretion in response to the P6 outer membrane protein. In the lymphocyte transformation assay, stimulation index of adenoid lymphocytes stimulated by P6 in otitis children (2.34 +/- 0.25) was significantly lower than that in non-otitis children (3.91 +/- 0.64, p <0.05). The number of IgM as well as IgA secreting cells after 8 days' culture with P6 were significantly smaller in otitis children (IgM: 7,534 +/- 2,843/10(6) lymphocyte; IgA: 1,573 +/- 620/10(6) lymphocyte) than those in non-otitis children (IgM: 12,994 +/- 2,533, p <0.05; IgA: 2,828 +/- 528, p <0.05). These data suggest that P6 protein is a target for the cellular immune response of the adenoid, and failure of adenoid lymphocytes to recognize it as a specific immunogen may be one of the causes of recurrent otitis media. SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/9082766/Adenoid_lymphocyte_responses_to_outer_membrane_protein_P6_of_nontypable_Haemophilus_influenzae_in_children_with_and_without_otitis_media_ L2 - http://www.diseaseinfosearch.org/result/3211 DB - PRIME DP - Unbound Medicine ER -