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Helicobacter pylori infection and the risk of gastric cancer among the Korean population.
J Gastroenterol Hepatol 1997; 12(2):100-3JG

Abstract

Helicobacter pylori infection has been associated with chronic atrophic gastritis, a precursor of gastric cancer. We conducted a prospective, case-controlled study to investigate whether H. pylori infection increases the risk of gastric cancer in Korean people with a high risk of gastric cancer. We enrolled 160 gastric cancer patients who were confirmed by endoscopic biopsy during 1994 and 160 age-matched control subjects with non-ulcer dyspepsia were compared to document the relationship between H. pylori infection and gastric cancer. The presence of H. pylori infection was determined by the rapid urease test and/or histology by Wright-Giemsa staining. The overall presence of H. pylori infection was 60% in gastric cancer patients and 51.9% in age-matched control subjects (odds ratio 1.39; 95% confidence interval 0.894-2.17; P = 0.143). Carcinomas of cardia, body and antrum were not associated with H. pylori infection (odds ratio 1.43, 1.69 and 1.29, respectively; 95% confidence interval, 0.271-7.52, 0.787-3.62 and 0.689-2.43, respectively; P = 0.178, 0.177 and 0.642, respectively) nor was the intestinal or diffuse type of cancer (odds ratio 1.39 and 1.40, respectively; 95% confidence interval 0.791-2.45 and 0.681-2.87, respectively; P = 0.250 and 0.835, respectively). Gender was not a risk for gastric cancer. In contrast to previous studies, these results do not provide evidence of H. pylori infection for gastric carcinogenesis in Korea.

Authors+Show Affiliations

Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9083909

Citation

Kim, H Y., et al. "Helicobacter Pylori Infection and the Risk of Gastric Cancer Among the Korean Population." Journal of Gastroenterology and Hepatology, vol. 12, no. 2, 1997, pp. 100-3.
Kim HY, Cho BD, Chang WK, et al. Helicobacter pylori infection and the risk of gastric cancer among the Korean population. J Gastroenterol Hepatol. 1997;12(2):100-3.
Kim, H. Y., Cho, B. D., Chang, W. K., Kim, D. J., Kim, Y. B., Park, C. K., ... Yoo, J. Y. (1997). Helicobacter pylori infection and the risk of gastric cancer among the Korean population. Journal of Gastroenterology and Hepatology, 12(2), pp. 100-3.
Kim HY, et al. Helicobacter Pylori Infection and the Risk of Gastric Cancer Among the Korean Population. J Gastroenterol Hepatol. 1997;12(2):100-3. PubMed PMID: 9083909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and the risk of gastric cancer among the Korean population. AU - Kim,H Y, AU - Cho,B D, AU - Chang,W K, AU - Kim,D J, AU - Kim,Y B, AU - Park,C K, AU - Shin,H S, AU - Yoo,J Y, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 100 EP - 3 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 12 IS - 2 N2 - Helicobacter pylori infection has been associated with chronic atrophic gastritis, a precursor of gastric cancer. We conducted a prospective, case-controlled study to investigate whether H. pylori infection increases the risk of gastric cancer in Korean people with a high risk of gastric cancer. We enrolled 160 gastric cancer patients who were confirmed by endoscopic biopsy during 1994 and 160 age-matched control subjects with non-ulcer dyspepsia were compared to document the relationship between H. pylori infection and gastric cancer. The presence of H. pylori infection was determined by the rapid urease test and/or histology by Wright-Giemsa staining. The overall presence of H. pylori infection was 60% in gastric cancer patients and 51.9% in age-matched control subjects (odds ratio 1.39; 95% confidence interval 0.894-2.17; P = 0.143). Carcinomas of cardia, body and antrum were not associated with H. pylori infection (odds ratio 1.43, 1.69 and 1.29, respectively; 95% confidence interval, 0.271-7.52, 0.787-3.62 and 0.689-2.43, respectively; P = 0.178, 0.177 and 0.642, respectively) nor was the intestinal or diffuse type of cancer (odds ratio 1.39 and 1.40, respectively; 95% confidence interval 0.791-2.45 and 0.681-2.87, respectively; P = 0.250 and 0.835, respectively). Gender was not a risk for gastric cancer. In contrast to previous studies, these results do not provide evidence of H. pylori infection for gastric carcinogenesis in Korea. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/9083909/Helicobacter_pylori_infection_and_the_risk_of_gastric_cancer_among_the_Korean_population_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=1997&volume=12&issue=2&spage=100 DB - PRIME DP - Unbound Medicine ER -