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Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration.
J Neuroendocrinol. 1997 Mar; 9(3):201-5.JN

Abstract

When administered intravenously (i.v.) in a pulsatile mode during the first half of the night to young normal controls, growth hormone-releasing hormone (GHRH) results in increased growth hormone (GH) plasma levels and slow wave sleep (SWS) and blunted cortisol release. In the present study we investigated whether GHRH has the same effects when administered in the early morning. Seven normal young male volunteers had 2 sessions each in the sleep laboratory (23.00 to 10.00 h) during which the secretion of GH, cortisol and corticotropin (ACTH) and polygraphic recording were monitored. Verum (4 bolus injections of 50 micrograms GHRH) or placebo were injected i.v. at 04.00, 05.00, 06.00 and 07.00 h. GHRH stimulated GH plasma levels significantly whereas cortisol and ACTH were not altered. In the sleep-electroencephalogram, only rapid-eye-movement density was decreased significantly during the period of active medication; all other sleep parameters were unaffected. We suggest that the physiological occurring high activity of the hypothalamic-pituitary-adrenocortical(HPA) system in the early morning prevents the effects of GHRH on cortisol plasma levels and SWS. Thus GHRH administered to healthy young men in the early morning hours has the same effect as GHRH administered during the first half of the night to patients with major depression who have HPA hyperactivity throughout the day.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9089471

Citation

Schier, T, et al. "Changes in Sleep-endocrine Activity After Growth Hormone-releasing Hormone Depend On Time of Administration." Journal of Neuroendocrinology, vol. 9, no. 3, 1997, pp. 201-5.
Schier T, Guldner J, Colla M, et al. Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. J Neuroendocrinol. 1997;9(3):201-5.
Schier, T., Guldner, J., Colla, M., Holsboer, F., & Steiger, A. (1997). Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. Journal of Neuroendocrinology, 9(3), 201-5.
Schier T, et al. Changes in Sleep-endocrine Activity After Growth Hormone-releasing Hormone Depend On Time of Administration. J Neuroendocrinol. 1997;9(3):201-5. PubMed PMID: 9089471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. AU - Schier,T, AU - Guldner,J, AU - Colla,M, AU - Holsboer,F, AU - Steiger,A, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 201 EP - 5 JF - Journal of neuroendocrinology JO - J Neuroendocrinol VL - 9 IS - 3 N2 - When administered intravenously (i.v.) in a pulsatile mode during the first half of the night to young normal controls, growth hormone-releasing hormone (GHRH) results in increased growth hormone (GH) plasma levels and slow wave sleep (SWS) and blunted cortisol release. In the present study we investigated whether GHRH has the same effects when administered in the early morning. Seven normal young male volunteers had 2 sessions each in the sleep laboratory (23.00 to 10.00 h) during which the secretion of GH, cortisol and corticotropin (ACTH) and polygraphic recording were monitored. Verum (4 bolus injections of 50 micrograms GHRH) or placebo were injected i.v. at 04.00, 05.00, 06.00 and 07.00 h. GHRH stimulated GH plasma levels significantly whereas cortisol and ACTH were not altered. In the sleep-electroencephalogram, only rapid-eye-movement density was decreased significantly during the period of active medication; all other sleep parameters were unaffected. We suggest that the physiological occurring high activity of the hypothalamic-pituitary-adrenocortical(HPA) system in the early morning prevents the effects of GHRH on cortisol plasma levels and SWS. Thus GHRH administered to healthy young men in the early morning hours has the same effect as GHRH administered during the first half of the night to patients with major depression who have HPA hyperactivity throughout the day. SN - 0953-8194 UR - https://www.unboundmedicine.com/medline/citation/9089471/Changes_in_sleep_endocrine_activity_after_growth_hormone_releasing_hormone_depend_on_time_of_administration_ L2 - https://doi.org/10.1046/j.1365-2826.1997.00565.x DB - PRIME DP - Unbound Medicine ER -