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Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia.

Abstract

The fatty acid compositions of serum phospholipids and cholesterol esters and direct bilirubinemia were determined in 11 children with cholestasis due to extrahepatic biliary atresia. The levels of the different fatty acids in these lipid classes were compared with those of 22 appropriate controls and correlations with conjugated bilirubinemia were calculated. Significant differences were found in the levels of several fatty acids in these lipid classes, some of which were related to conjugated bilirubinemia. Relationships between fatty acids in phospholipids and cholesterol esters which exist in the control group were either absent or different in the patient group. The results found are compatible with the concept that malabsorption, overflow in blood of phospholipids, which are excreted in bile in healthy individuals, and liver disease per se contribute to the deviating fatty acid compositions. They suggest that administration in the diet may be required of preformed long chain polyunsaturated fatty acids in an easily absorbable form.

Authors+Show Affiliations

,

Department of Pediatrics, University Hospital, Ghent, Belgium.

,

Source

MeSH

Biliary Atresia
Case-Control Studies
Cholestasis
Cholesterol Esters
Fatty Acids
Fatty Acids, Essential
Humans
Hyperbilirubinemia
Infant
Liver Transplantation
Phospholipids
Portoenterostomy, Hepatic

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9089798

Citation

Robberecht, E, et al. "Several Mechanisms Contribute to the Abnormal Fatty Acid Composition of Serum Phospholipids and Cholesterol Esters in Cholestatic Children With Extrahepatic Biliary Atresia." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 56, no. 3, 1997, pp. 199-204.
Robberecht E, Koletzko B, Christophe A. Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia. Prostaglandins Leukot Essent Fatty Acids. 1997;56(3):199-204.
Robberecht, E., Koletzko, B., & Christophe, A. (1997). Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 56(3), pp. 199-204.
Robberecht E, Koletzko B, Christophe A. Several Mechanisms Contribute to the Abnormal Fatty Acid Composition of Serum Phospholipids and Cholesterol Esters in Cholestatic Children With Extrahepatic Biliary Atresia. Prostaglandins Leukot Essent Fatty Acids. 1997;56(3):199-204. PubMed PMID: 9089798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia. AU - Robberecht,E, AU - Koletzko,B, AU - Christophe,A, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 199 EP - 204 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 56 IS - 3 N2 - The fatty acid compositions of serum phospholipids and cholesterol esters and direct bilirubinemia were determined in 11 children with cholestasis due to extrahepatic biliary atresia. The levels of the different fatty acids in these lipid classes were compared with those of 22 appropriate controls and correlations with conjugated bilirubinemia were calculated. Significant differences were found in the levels of several fatty acids in these lipid classes, some of which were related to conjugated bilirubinemia. Relationships between fatty acids in phospholipids and cholesterol esters which exist in the control group were either absent or different in the patient group. The results found are compatible with the concept that malabsorption, overflow in blood of phospholipids, which are excreted in bile in healthy individuals, and liver disease per se contribute to the deviating fatty acid compositions. They suggest that administration in the diet may be required of preformed long chain polyunsaturated fatty acids in an easily absorbable form. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/9089798/Several_mechanisms_contribute_to_the_abnormal_fatty_acid_composition_of_serum_phospholipids_and_cholesterol_esters_in_cholestatic_children_with_extrahepatic_biliary_atresia_ L2 - http://www.diseaseinfosearch.org/result/836 DB - PRIME DP - Unbound Medicine ER -