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Triterpene saponins from Cyclamen mirabile and their biological activities.
J Nat Prod. 1997 Mar; 60(3):315-8.JN

Abstract

Six saponins, cyclaminorin (1), deglucocyclamin (2), cyclacoumin (3), cyclamin (4), isocyclamin (5), and mirabilin (6) were isolated from the tubers of Cyclamen mirabile. Compound 6 is a new natural compound, and its structure was established as 3-[O-beta-[[beta-D-xylopyranosyl-(1-->2)]- [beta-D-glycopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->4)]-[be ta-D- glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl]-3 beta,16 alpha,28-trihydroxyolean-12-en-30-oic acid (6). The structure elucidation of this compound was accomplished using both spectral and chemical methods. Antimicrobial and uterocontractile activities of the saponins were also investigated.

Authors+Show Affiliations

Caliş T
Department of Pharmacognosy, Hacettepe University, Faculty of Pharmacy, Ankara, Turkey.
Satana ME
No affiliation info available
Yürüker A
No affiliation info available
Kelican P
No affiliation info available
Demirdamar R
No affiliation info available
Alaçam R
No affiliation info available
Tanker N
No affiliation info available
Rüegger H
No affiliation info available
Sticher O
No affiliation info available

MeSH

AcetylcholineAnimalsAnti-Bacterial AgentsBacteriaFemaleIn Vitro TechniquesMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsOleanolic AcidPlant RootsPlants, MedicinalRatsSaponinsSpectrometry, Mass, Fast Atom BombardmentTriterpenesUterine Contraction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9090874

Citation

Caliş, T, et al. "Triterpene Saponins From Cyclamen Mirabile and Their Biological Activities." Journal of Natural Products, vol. 60, no. 3, 1997, pp. 315-8.
Caliş T, Satana ME, Yürüker A, et al. Triterpene saponins from Cyclamen mirabile and their biological activities. J Nat Prod. 1997;60(3):315-8.
Caliş, T., Satana, M. E., Yürüker, A., Kelican, P., Demirdamar, R., Alaçam, R., Tanker, N., Rüegger, H., & Sticher, O. (1997). Triterpene saponins from Cyclamen mirabile and their biological activities. Journal of Natural Products, 60(3), 315-8.
Caliş T, et al. Triterpene Saponins From Cyclamen Mirabile and Their Biological Activities. J Nat Prod. 1997;60(3):315-8. PubMed PMID: 9090874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triterpene saponins from Cyclamen mirabile and their biological activities. AU - Caliş,T, AU - Satana,M E, AU - Yürüker,A, AU - Kelican,P, AU - Demirdamar,R, AU - Alaçam,R, AU - Tanker,N, AU - Rüegger,H, AU - Sticher,O, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 315 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 60 IS - 3 N2 - Six saponins, cyclaminorin (1), deglucocyclamin (2), cyclacoumin (3), cyclamin (4), isocyclamin (5), and mirabilin (6) were isolated from the tubers of Cyclamen mirabile. Compound 6 is a new natural compound, and its structure was established as 3-[O-beta-[[beta-D-xylopyranosyl-(1-->2)]- [beta-D-glycopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->4)]-[be ta-D- glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl]-3 beta,16 alpha,28-trihydroxyolean-12-en-30-oic acid (6). The structure elucidation of this compound was accomplished using both spectral and chemical methods. Antimicrobial and uterocontractile activities of the saponins were also investigated. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/9090874/Triterpene_saponins_from_Cyclamen_mirabile_and_their_biological_activities_ L2 - https://doi.org/10.1021/np960658j DB - PRIME DP - Unbound Medicine ER -