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Overview of the safety of newer antiepileptic drugs.
Epilepsia. 1997; 38 Suppl 1:S45-51.E

Abstract

Standard antiepileptic drugs (AEDs) are associated with a wide variety of acute and chronic adverse events and with many interactions with each other and with non-AEDs that complicate patient management. The safety and interaction profiles of the newer AEDs have also been intensively studied. Safety data are available for six of the newer AEDs, lamotrigine (LTG), vigabatrin (VGB), gabapentin (GBP), tiagabine (TGB), felbamate (FBM), and topiramate (TPM). The potential for the most recently developed AEDs for producing rare idiosyncratic reactions cannot be ascertained until additional patient exposures have been reported from careful postmarketing surveillance.

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Authors+Show Affiliations

Shorvon S
National Hospital for Neurology and Neurosurgery, London, England.
Stefan H
No affiliation info available

MeSH

AcetatesAminesAnticonvulsantsClinical Trials as TopicCyclohexanecarboxylic AcidsDrug InteractionsEpilepsyFelbamateFructoseGabapentinHumansLamotrigineNipecotic AcidsPhenylcarbamatesPropylene GlycolsTiagabineTopiramateTriazinesVigabatringamma-Aminobutyric Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9092960

Citation

Shorvon, S, and H Stefan. "Overview of the Safety of Newer Antiepileptic Drugs." Epilepsia, vol. 38 Suppl 1, 1997, pp. S45-51.
Shorvon S, Stefan H. Overview of the safety of newer antiepileptic drugs. Epilepsia. 1997;38 Suppl 1:S45-51.
Shorvon, S., & Stefan, H. (1997). Overview of the safety of newer antiepileptic drugs. Epilepsia, 38 Suppl 1, S45-51.
Shorvon S, Stefan H. Overview of the Safety of Newer Antiepileptic Drugs. Epilepsia. 1997;38 Suppl 1:S45-51. PubMed PMID: 9092960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overview of the safety of newer antiepileptic drugs. AU - Shorvon,S, AU - Stefan,H, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - S45 EP - 51 JF - Epilepsia JO - Epilepsia VL - 38 Suppl 1 N2 - Standard antiepileptic drugs (AEDs) are associated with a wide variety of acute and chronic adverse events and with many interactions with each other and with non-AEDs that complicate patient management. The safety and interaction profiles of the newer AEDs have also been intensively studied. Safety data are available for six of the newer AEDs, lamotrigine (LTG), vigabatrin (VGB), gabapentin (GBP), tiagabine (TGB), felbamate (FBM), and topiramate (TPM). The potential for the most recently developed AEDs for producing rare idiosyncratic reactions cannot be ascertained until additional patient exposures have been reported from careful postmarketing surveillance. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/9092960/Overview_of_the_safety_of_newer_antiepileptic_drugs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0013-9580&date=1997&volume=38&issue=&spage=S45 DB - PRIME DP - Unbound Medicine ER -