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Effects of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women.
Am J Clin Nutr 1997; 65(4):1027-33AJ

Abstract

The effects of variations in dietary carbohydrate and fat on various aspects of carbohydrate and lipoprotein metabolism were evaluated in 10 healthy, postmenopausal women. The two diets were isoenergetic, assigned in random fashion, and consisted (as a % of total energy) of 15% protein, 60% carbohydrate, and 25% fat (60%-carbohydrate diet) or 15% protein, 40% carbohydrate, and 45% fat (40%-carbohydrate diet). Fasting plasma triacylglycerol, very-low-density-lipoprotein (VLDL) triacylglycerol, and VLDL-cholesterol concentrations were higher (P < 0.05-0.001) after the 60%-carbohydrate diet, whereas high-density-lipoprotein (HDL) cholesterol was lower (P < 0.05). Plasma insulin and triacylglycerol concentrations were also higher (P < 0.001) from 0800 to 0000 with the 60%-carbohydrate diet than with the 40%-carbohydrate diet. In addition, when vitamin A was given with the noon meal, the ensuing concentrations of retinyl palmitate were also higher after ingestion of the 60%-carbohydrate diet. Resistance to insulin-mediated glucose disposal, quantified at baseline by determining the steady state plasma glucose (SSPG) concentration at the end of a 180-min infusion of somatostatin, insulin, and glucose, correlated with the incremental increases in postprandial concentrations of plasma glucose (r = 0.68, P = 0.06), insulin (r = 0.82, P < 0.02), triacylglycerol (r = 0.77, P < 0.05), and retinyl palmitate (r = 0.68, P = 0.06) and with the Sf > 400 triacylglycerol (r = 0.77, P < 0.05), Sf 20-400 triacylglycerol (r = 0.72, P < 0.05), and Sf > 400 retinyl palmitate (r = 0.75, P < 0.01) lipoprotein fractions. Because all of these changes would increase risk of ischemic heart disease in postmenopausal women, it seems reasonable to question the wisdom of recommending that postmenopausal women consume low-fat, high-carbohydrate diets.

Authors+Show Affiliations

Department of Medicine, Stanford University School of Medicine, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9094889

Citation

Jeppesen, J, et al. "Effects of Low-fat, High-carbohydrate Diets On Risk Factors for Ischemic Heart Disease in Postmenopausal Women." The American Journal of Clinical Nutrition, vol. 65, no. 4, 1997, pp. 1027-33.
Jeppesen J, Schaaf P, Jones C, et al. Effects of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women. Am J Clin Nutr. 1997;65(4):1027-33.
Jeppesen, J., Schaaf, P., Jones, C., Zhou, M. Y., Chen, Y. D., & Reaven, G. M. (1997). Effects of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women. The American Journal of Clinical Nutrition, 65(4), pp. 1027-33.
Jeppesen J, et al. Effects of Low-fat, High-carbohydrate Diets On Risk Factors for Ischemic Heart Disease in Postmenopausal Women. Am J Clin Nutr. 1997;65(4):1027-33. PubMed PMID: 9094889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women. AU - Jeppesen,J, AU - Schaaf,P, AU - Jones,C, AU - Zhou,M Y, AU - Chen,Y D, AU - Reaven,G M, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 1027 EP - 33 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 65 IS - 4 N2 - The effects of variations in dietary carbohydrate and fat on various aspects of carbohydrate and lipoprotein metabolism were evaluated in 10 healthy, postmenopausal women. The two diets were isoenergetic, assigned in random fashion, and consisted (as a % of total energy) of 15% protein, 60% carbohydrate, and 25% fat (60%-carbohydrate diet) or 15% protein, 40% carbohydrate, and 45% fat (40%-carbohydrate diet). Fasting plasma triacylglycerol, very-low-density-lipoprotein (VLDL) triacylglycerol, and VLDL-cholesterol concentrations were higher (P < 0.05-0.001) after the 60%-carbohydrate diet, whereas high-density-lipoprotein (HDL) cholesterol was lower (P < 0.05). Plasma insulin and triacylglycerol concentrations were also higher (P < 0.001) from 0800 to 0000 with the 60%-carbohydrate diet than with the 40%-carbohydrate diet. In addition, when vitamin A was given with the noon meal, the ensuing concentrations of retinyl palmitate were also higher after ingestion of the 60%-carbohydrate diet. Resistance to insulin-mediated glucose disposal, quantified at baseline by determining the steady state plasma glucose (SSPG) concentration at the end of a 180-min infusion of somatostatin, insulin, and glucose, correlated with the incremental increases in postprandial concentrations of plasma glucose (r = 0.68, P = 0.06), insulin (r = 0.82, P < 0.02), triacylglycerol (r = 0.77, P < 0.05), and retinyl palmitate (r = 0.68, P = 0.06) and with the Sf > 400 triacylglycerol (r = 0.77, P < 0.05), Sf 20-400 triacylglycerol (r = 0.72, P < 0.05), and Sf > 400 retinyl palmitate (r = 0.75, P < 0.01) lipoprotein fractions. Because all of these changes would increase risk of ischemic heart disease in postmenopausal women, it seems reasonable to question the wisdom of recommending that postmenopausal women consume low-fat, high-carbohydrate diets. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9094889/Effects_of_low_fat_high_carbohydrate_diets_on_risk_factors_for_ischemic_heart_disease_in_postmenopausal_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/65.4.1027 DB - PRIME DP - Unbound Medicine ER -