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Sunscreen lotions prevent ultraviolet radiation-induced suppression of antitumor immune responses.
Int J Cancer. 1997 Mar 28; 71(1):94-102.IJ

Abstract

Exposure to subcarcinogenic doses of ultraviolet (UV) radiation suppresses tumor immunity, thus permitting the emergence and growth of highly immunogenic skin cancers in mice. Sunscreens prevent UV carcinogenesis; however, there are conflicting reports regarding their ability to block UV-induced tumor immune suppression. In this study we critically evaluated the effects of UV spectrum and dose on the tumor immune protective capacity of 4 marketed sunscreen lotions with labeled sun protection factors (SPF) 8-45. Effective tumor immune suppression doses (TISD), i.e., the lowest dose tested to induce outgrowth of transplanted nonmelanoma skin tumors in 100% of UV-exposed C3H mice, were established for 3 different UV sources. TISD were significantly lower for unfiltered (FS) and Kodacel-filtered (KFS) UVB-type FS20 sunlamps compared with a filtered xenon arc lamp solar simulator. Sunscreen tumor immune protection levels matched those predicted by their labeled SPF when sunscreen-protected mice were exposed to a fixed TISD of solar simulator UV radiation. SPF 30 and 45 sunscreens also blocked activation of tumor antigen-specific suppressor T-lymphocytes in mice exposed to solar simulator UV radiation. In comparison, sunscreens with SPF > or = 15 provided partial to complete protection, as measured by tumor incidence, for mice exposed to UV radiation from KFS. All sunscreens tested reduced tumor growth rates in KFS UV-exposed mice. None of the sunscreens tested provided measurable tumor immune protection for mice exposed to FS UV radiation. Thus, sunscreen lotions provide an extent of tumor immune protection consistent with their labeled SPF when appropriate testing conditions are employed.

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Authors+Show Affiliations

Roberts LK
Department of Research and Development, Schering-Plough HealthCare Products, Memphis, TN 38151, USA. LEE.ROBERTS@SPCORP.COM
Beasley DG
No affiliation info available

MeSH

AnimalsAntigens, NeoplasmDose-Response Relationship, DrugDose-Response Relationship, RadiationFemaleMiceMice, Inbred C3HNeoplasm TransplantationSkin NeoplasmsSunscreening AgentsT-Lymphocytes, RegulatoryTime FactorsUltraviolet Rays

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9096671

Citation

Roberts, L K., and D G. Beasley. "Sunscreen Lotions Prevent Ultraviolet Radiation-induced Suppression of Antitumor Immune Responses." International Journal of Cancer, vol. 71, no. 1, 1997, pp. 94-102.
Roberts LK, Beasley DG. Sunscreen lotions prevent ultraviolet radiation-induced suppression of antitumor immune responses. Int J Cancer. 1997;71(1):94-102.
Roberts, L. K., & Beasley, D. G. (1997). Sunscreen lotions prevent ultraviolet radiation-induced suppression of antitumor immune responses. International Journal of Cancer, 71(1), 94-102.
Roberts LK, Beasley DG. Sunscreen Lotions Prevent Ultraviolet Radiation-induced Suppression of Antitumor Immune Responses. Int J Cancer. 1997 Mar 28;71(1):94-102. PubMed PMID: 9096671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sunscreen lotions prevent ultraviolet radiation-induced suppression of antitumor immune responses. AU - Roberts,L K, AU - Beasley,D G, PY - 1997/3/28/pubmed PY - 2000/6/20/medline PY - 1997/3/28/entrez SP - 94 EP - 102 JF - International journal of cancer JO - Int J Cancer VL - 71 IS - 1 N2 - Exposure to subcarcinogenic doses of ultraviolet (UV) radiation suppresses tumor immunity, thus permitting the emergence and growth of highly immunogenic skin cancers in mice. Sunscreens prevent UV carcinogenesis; however, there are conflicting reports regarding their ability to block UV-induced tumor immune suppression. In this study we critically evaluated the effects of UV spectrum and dose on the tumor immune protective capacity of 4 marketed sunscreen lotions with labeled sun protection factors (SPF) 8-45. Effective tumor immune suppression doses (TISD), i.e., the lowest dose tested to induce outgrowth of transplanted nonmelanoma skin tumors in 100% of UV-exposed C3H mice, were established for 3 different UV sources. TISD were significantly lower for unfiltered (FS) and Kodacel-filtered (KFS) UVB-type FS20 sunlamps compared with a filtered xenon arc lamp solar simulator. Sunscreen tumor immune protection levels matched those predicted by their labeled SPF when sunscreen-protected mice were exposed to a fixed TISD of solar simulator UV radiation. SPF 30 and 45 sunscreens also blocked activation of tumor antigen-specific suppressor T-lymphocytes in mice exposed to solar simulator UV radiation. In comparison, sunscreens with SPF > or = 15 provided partial to complete protection, as measured by tumor incidence, for mice exposed to UV radiation from KFS. All sunscreens tested reduced tumor growth rates in KFS UV-exposed mice. None of the sunscreens tested provided measurable tumor immune protection for mice exposed to FS UV radiation. Thus, sunscreen lotions provide an extent of tumor immune protection consistent with their labeled SPF when appropriate testing conditions are employed. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/9096671/Sunscreen_lotions_prevent_ultraviolet_radiation_induced_suppression_of_antitumor_immune_responses_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1997&volume=71&issue=1&spage=94 DB - PRIME DP - Unbound Medicine ER -