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A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease.
Biol Psychiatry 1997; 41(8):851-6BP

Abstract

A prior history of depression and the epsilon 4 allele of apolipoprotein E (APOE) have each been associated with development of Alzheimer's disease (AD). In a sample of 142 elderly twins from a large study of dementia, we examined the relation of major depression, APOE genotype and AD using time-dependent proportional hazards models. Compared against the risk for AD with no history of depression and no epsilon 4 allele, the risk ratio for AD with two epsilon 4 alleles was 2.87 (C.I. = 1.56-5.28), with one epsilon 4 allele, 1.82 (C.I. = 1.09-3.04) and with late-onset depression and no epsilon 4 allele, 2.95 (C.I. = 1.55-5.62). There was no suggestion of an interaction between prior depression and APOE genotype in their effects on AD risk. Results were similar when the sample was stratified by twin pair, so that a single genetic marker is unlikely to explain the relation among depression, APOE, and dementia. Risk ratios declined substantially with increasing intervals between the onset of depression and AD. Thus, for many individuals, the association of depression and AD may reflect the occurrence of prodromal depressive symptoms rather than a true risk relationship.

Authors+Show Affiliations

Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

9099411

Citation

Steffens, D C., et al. "A Twin Study of Late-onset Depression and Apolipoprotein E Epsilon 4 as Risk Factors for Alzheimer's Disease." Biological Psychiatry, vol. 41, no. 8, 1997, pp. 851-6.
Steffens DC, Plassman BL, Helms MJ, et al. A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biol Psychiatry. 1997;41(8):851-6.
Steffens, D. C., Plassman, B. L., Helms, M. J., Welsh-Bohmer, K. A., Saunders, A. M., & Breitner, J. C. (1997). A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biological Psychiatry, 41(8), pp. 851-6.
Steffens DC, et al. A Twin Study of Late-onset Depression and Apolipoprotein E Epsilon 4 as Risk Factors for Alzheimer's Disease. Biol Psychiatry. 1997 Apr 15;41(8):851-6. PubMed PMID: 9099411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. AU - Steffens,D C, AU - Plassman,B L, AU - Helms,M J, AU - Welsh-Bohmer,K A, AU - Saunders,A M, AU - Breitner,J C, PY - 1997/4/15/pubmed PY - 1997/4/15/medline PY - 1997/4/15/entrez SP - 851 EP - 6 JF - Biological psychiatry JO - Biol. Psychiatry VL - 41 IS - 8 N2 - A prior history of depression and the epsilon 4 allele of apolipoprotein E (APOE) have each been associated with development of Alzheimer's disease (AD). In a sample of 142 elderly twins from a large study of dementia, we examined the relation of major depression, APOE genotype and AD using time-dependent proportional hazards models. Compared against the risk for AD with no history of depression and no epsilon 4 allele, the risk ratio for AD with two epsilon 4 alleles was 2.87 (C.I. = 1.56-5.28), with one epsilon 4 allele, 1.82 (C.I. = 1.09-3.04) and with late-onset depression and no epsilon 4 allele, 2.95 (C.I. = 1.55-5.62). There was no suggestion of an interaction between prior depression and APOE genotype in their effects on AD risk. Results were similar when the sample was stratified by twin pair, so that a single genetic marker is unlikely to explain the relation among depression, APOE, and dementia. Risk ratios declined substantially with increasing intervals between the onset of depression and AD. Thus, for many individuals, the association of depression and AD may reflect the occurrence of prodromal depressive symptoms rather than a true risk relationship. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/9099411/A_twin_study_of_late_onset_depression_and_apolipoprotein_E_epsilon_4_as_risk_factors_for_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(96)00247-8 DB - PRIME DP - Unbound Medicine ER -