Citation
Chandrasekharappa, S C., et al. "Positional Cloning of the Gene for Multiple Endocrine Neoplasia-type 1." Science (New York, N.Y.), vol. 276, no. 5311, 1997, pp. 404-7.
Chandrasekharappa SC, Guru SC, Manickam P, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997;276(5311):404-7.
Chandrasekharappa, S. C., Guru, S. C., Manickam, P., Olufemi, S. E., Collins, F. S., Emmert-Buck, M. R., Debelenko, L. V., Zhuang, Z., Lubensky, I. A., Liotta, L. A., Crabtree, J. S., Wang, Y., Roe, B. A., Weisemann, J., Boguski, M. S., Agarwal, S. K., Kester, M. B., Kim, Y. S., Heppner, C., ... Marx, S. J. (1997). Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (New York, N.Y.), 276(5311), 404-7.
Chandrasekharappa SC, et al. Positional Cloning of the Gene for Multiple Endocrine Neoplasia-type 1. Science. 1997 Apr 18;276(5311):404-7. PubMed PMID: 9103196.
TY - JOUR
T1 - Positional cloning of the gene for multiple endocrine neoplasia-type 1.
AU - Chandrasekharappa,S C,
AU - Guru,S C,
AU - Manickam,P,
AU - Olufemi,S E,
AU - Collins,F S,
AU - Emmert-Buck,M R,
AU - Debelenko,L V,
AU - Zhuang,Z,
AU - Lubensky,I A,
AU - Liotta,L A,
AU - Crabtree,J S,
AU - Wang,Y,
AU - Roe,B A,
AU - Weisemann,J,
AU - Boguski,M S,
AU - Agarwal,S K,
AU - Kester,M B,
AU - Kim,Y S,
AU - Heppner,C,
AU - Dong,Q,
AU - Spiegel,A M,
AU - Burns,A L,
AU - Marx,S J,
PY - 1997/4/18/pubmed
PY - 1997/4/18/medline
PY - 1997/4/18/entrez
SP - 404
EP - 7
JF - Science (New York, N.Y.)
JO - Science
VL - 276
IS - 5311
N2 - Multiple endocrine neoplasia-type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and the anterior pituitary. DNA sequencing from a previously identified minimal interval on chromosome 11q13 identified several candidate genes, one of which contained 12 different frameshift, nonsense, missense, and in-frame deletion mutations in 14 probands from 15 families. The MEN1 gene contains 10 exons and encodes a ubiquitously expressed 2.8-kilobase transcript. The predicted 610-amino acid protein product, termed menin, exhibits no apparent similarities to any previously known proteins. The identification of MEN1 will enable improved understanding of the mechanism of endocrine tumorigenesis and should facilitate early diagnosis.
SN - 0036-8075
UR - https://www.unboundmedicine.com/medline/citation/9103196/Positional_cloning_of_the_gene_for_multiple_endocrine_neoplasia_type_1_
L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=9103196
DB - PRIME
DP - Unbound Medicine
ER -