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Assessment of plasma fibronectin in malnourished Nigerian children.

Abstract

BACKGROUND

Severe malnutrition is associated with septic infections. The concentrations of fibronectin, albumin, and transferrin in plasma were measured in three groups of children with protein-energy malnutrition, aged 1-3 years, each group comprising 20 children. The aim of which was to test whether plasma fibronectin, being an opsonic protein, was reduced in such children, and if it was a useful index for assessing the severity of malnutrition.

METHODS

The concentrations of fibronectin, albumin, and transferrin in plasma were studied by enzyme immunoassay/ immunoblotting, spectrophotometry and immunoturbidimetry respectively.

RESULTS

All values were significantly lower in the patients with malnutrition than in the age- and sex-matched well-nourished Nigerian reference children. Within the malnourished group, the fibronectin value was evenly reduced in all subgroups. Albumin and transferrin values were lowest in the patients with kwashiorkor, highest in the marasmic patients, and intermediate in the patients with marasmic kwashiorkor; the values correlated mutually in individual cases as well, but not with the fibronectin levels. Neither plasma fibronectin fragmentation nor tissue fibronectin was detected in any patient with malnutrition or in the reference subjects.

CONCLUSIONS

The reduced plasma fibronectin values in these patients may be due to reduced synthesis by the liver, as evidenced by the equally reduced albumin and transferrin concentrations and/or to the multiple infections characteristic of the patients.

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  • Authors+Show Affiliations

    ,

    Department of Virology, University of Helsinki, Finland.

    , , , ,

    Source

    MeSH

    Biomarkers
    Child, Preschool
    Cohort Studies
    Fibronectins
    Humans
    Immunoblotting
    Infant
    Kwashiorkor
    Nigeria
    Nutrition Disorders
    Protein-Energy Malnutrition
    Reference Values
    Regression Analysis
    Serum Albumin
    Transferrin

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9106105

    Citation

    Akenami, F O., et al. "Assessment of Plasma Fibronectin in Malnourished Nigerian Children." Journal of Pediatric Gastroenterology and Nutrition, vol. 24, no. 2, 1997, pp. 183-8.
    Akenami FO, Koskiniemi M, Siimes MA, et al. Assessment of plasma fibronectin in malnourished Nigerian children. J Pediatr Gastroenterol Nutr. 1997;24(2):183-8.
    Akenami, F. O., Koskiniemi, M., Siimes, M. A., Ekanem, E. E., Bolarin, D. M., & Vaheri, A. (1997). Assessment of plasma fibronectin in malnourished Nigerian children. Journal of Pediatric Gastroenterology and Nutrition, 24(2), pp. 183-8.
    Akenami FO, et al. Assessment of Plasma Fibronectin in Malnourished Nigerian Children. J Pediatr Gastroenterol Nutr. 1997;24(2):183-8. PubMed PMID: 9106105.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Assessment of plasma fibronectin in malnourished Nigerian children. AU - Akenami,F O, AU - Koskiniemi,M, AU - Siimes,M A, AU - Ekanem,E E, AU - Bolarin,D M, AU - Vaheri,A, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 183 EP - 8 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 24 IS - 2 N2 - BACKGROUND: Severe malnutrition is associated with septic infections. The concentrations of fibronectin, albumin, and transferrin in plasma were measured in three groups of children with protein-energy malnutrition, aged 1-3 years, each group comprising 20 children. The aim of which was to test whether plasma fibronectin, being an opsonic protein, was reduced in such children, and if it was a useful index for assessing the severity of malnutrition. METHODS: The concentrations of fibronectin, albumin, and transferrin in plasma were studied by enzyme immunoassay/ immunoblotting, spectrophotometry and immunoturbidimetry respectively. RESULTS: All values were significantly lower in the patients with malnutrition than in the age- and sex-matched well-nourished Nigerian reference children. Within the malnourished group, the fibronectin value was evenly reduced in all subgroups. Albumin and transferrin values were lowest in the patients with kwashiorkor, highest in the marasmic patients, and intermediate in the patients with marasmic kwashiorkor; the values correlated mutually in individual cases as well, but not with the fibronectin levels. Neither plasma fibronectin fragmentation nor tissue fibronectin was detected in any patient with malnutrition or in the reference subjects. CONCLUSIONS: The reduced plasma fibronectin values in these patients may be due to reduced synthesis by the liver, as evidenced by the equally reduced albumin and transferrin concentrations and/or to the multiple infections characteristic of the patients. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/9106105/Assessment_of_plasma_fibronectin_in_malnourished_Nigerian_children_ L2 - http://Insights.ovid.com/pubmed?pmid=9106105 DB - PRIME DP - Unbound Medicine ER -