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Neuroprotection against oxidative stress by estrogens: structure-activity relationship.
Mol Pharmacol. 1997 Apr; 51(4):535-41.MP

Abstract

Oxidative stress-induced neuronal cell death has been implicated in different neurological disorders and neurodegenerative diseases; one such ailment is Alzheimer's disease. Using the Alzheimer's disease-associated amyloid beta protein, glutamate, hydrogen peroxide, and buthionine sulfoximine, we investigated the neuroprotective potential of estrogen against oxidative stress-induced cell death. We show that 17-beta-estradiol, its nonestrogenic stereoisomer, 17-alpha-estradiol, and some estradiol derivatives can prevent intracellular peroxide accumulation and, ultimately, the degeneration of primary neurons, clonal hippocampal cells, and cells in organotypic hippocampal slices. The neuroprotective antioxidant activity of estrogens is dependent on the presence of the hydroxyl group in the C3 position on the A ring of the steroid molecule but is independent of an activation of estrogen receptors.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany. chris@mpipsykl.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9106616

Citation

Behl, C, et al. "Neuroprotection Against Oxidative Stress By Estrogens: Structure-activity Relationship." Molecular Pharmacology, vol. 51, no. 4, 1997, pp. 535-41.
Behl C, Skutella T, Lezoualc'h F, et al. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol. 1997;51(4):535-41.
Behl, C., Skutella, T., Lezoualc'h, F., Post, A., Widmann, M., Newton, C. J., & Holsboer, F. (1997). Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Molecular Pharmacology, 51(4), 535-41.
Behl C, et al. Neuroprotection Against Oxidative Stress By Estrogens: Structure-activity Relationship. Mol Pharmacol. 1997;51(4):535-41. PubMed PMID: 9106616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotection against oxidative stress by estrogens: structure-activity relationship. AU - Behl,C, AU - Skutella,T, AU - Lezoualc'h,F, AU - Post,A, AU - Widmann,M, AU - Newton,C J, AU - Holsboer,F, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 535 EP - 41 JF - Molecular pharmacology JO - Mol Pharmacol VL - 51 IS - 4 N2 - Oxidative stress-induced neuronal cell death has been implicated in different neurological disorders and neurodegenerative diseases; one such ailment is Alzheimer's disease. Using the Alzheimer's disease-associated amyloid beta protein, glutamate, hydrogen peroxide, and buthionine sulfoximine, we investigated the neuroprotective potential of estrogen against oxidative stress-induced cell death. We show that 17-beta-estradiol, its nonestrogenic stereoisomer, 17-alpha-estradiol, and some estradiol derivatives can prevent intracellular peroxide accumulation and, ultimately, the degeneration of primary neurons, clonal hippocampal cells, and cells in organotypic hippocampal slices. The neuroprotective antioxidant activity of estrogens is dependent on the presence of the hydroxyl group in the C3 position on the A ring of the steroid molecule but is independent of an activation of estrogen receptors. SN - 0026-895X UR - https://www.unboundmedicine.com/medline/citation/9106616/Neuroprotection_against_oxidative_stress_by_estrogens:_structure_activity_relationship_ L2 - http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9106616 DB - PRIME DP - Unbound Medicine ER -