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Three-dimensional demonstration of melanocyte distribution of human hair follicles: special reference to the bulge area.
Acta Derm Venereol. 1997 Mar; 77(2):97-101.AD

Abstract

Melanocytes of human hair follicles were histochemically and immunohistochemically examined in two and three dimensions. EDTA-treated extracted anagen vellus and intermediate hair follicles showed that monoclonal murine antibody (MoAb) NKI/ beteb-reactive melanocytes were distributed from the infundibulum to the bulb. Melanocytes of the infundibulum and bulb were larger and more strongly stained with MoAb NKI/beteb than those of the middle portion below the sebaceous gland. Latter melanocytes showed less dendricity. Dendritic melanocytes were exclusively observed in the bulb as well as the bulge area of vellus and intermediate hair follicles, where they were variably melanized. In longitudinal and transverse sections of adult human scalp some keratinocytes of the outer root sheath of the bulge area were melanized compared to other parts. This phenomenon was independent of the hair cycle. These findings may be characteristic of bulge melanocytes and/or keratinocytes.

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Authors+Show Affiliations

Narisawa Y
Division of Dermatology, Department of Internal Medicine, Saga Medical School, Japan.
Kohda H
No affiliation info available
Tanaka T
No affiliation info available

MeSH

AdultBiopsyCulture TechniquesFaceHair FollicleHumansImmunohistochemistryMelanocytesReference ValuesScalp

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9111816

Citation

Narisawa, Y, et al. "Three-dimensional Demonstration of Melanocyte Distribution of Human Hair Follicles: Special Reference to the Bulge Area." Acta Dermato-venereologica, vol. 77, no. 2, 1997, pp. 97-101.
Narisawa Y, Kohda H, Tanaka T. Three-dimensional demonstration of melanocyte distribution of human hair follicles: special reference to the bulge area. Acta Derm Venereol. 1997;77(2):97-101.
Narisawa, Y., Kohda, H., & Tanaka, T. (1997). Three-dimensional demonstration of melanocyte distribution of human hair follicles: special reference to the bulge area. Acta Dermato-venereologica, 77(2), 97-101.
Narisawa Y, Kohda H, Tanaka T. Three-dimensional Demonstration of Melanocyte Distribution of Human Hair Follicles: Special Reference to the Bulge Area. Acta Derm Venereol. 1997;77(2):97-101. PubMed PMID: 9111816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-dimensional demonstration of melanocyte distribution of human hair follicles: special reference to the bulge area. AU - Narisawa,Y, AU - Kohda,H, AU - Tanaka,T, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 97 EP - 101 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 77 IS - 2 N2 - Melanocytes of human hair follicles were histochemically and immunohistochemically examined in two and three dimensions. EDTA-treated extracted anagen vellus and intermediate hair follicles showed that monoclonal murine antibody (MoAb) NKI/ beteb-reactive melanocytes were distributed from the infundibulum to the bulb. Melanocytes of the infundibulum and bulb were larger and more strongly stained with MoAb NKI/beteb than those of the middle portion below the sebaceous gland. Latter melanocytes showed less dendricity. Dendritic melanocytes were exclusively observed in the bulb as well as the bulge area of vellus and intermediate hair follicles, where they were variably melanized. In longitudinal and transverse sections of adult human scalp some keratinocytes of the outer root sheath of the bulge area were melanized compared to other parts. This phenomenon was independent of the hair cycle. These findings may be characteristic of bulge melanocytes and/or keratinocytes. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/9111816/Three_dimensional_demonstration_of_melanocyte_distribution_of_human_hair_follicles:_special_reference_to_the_bulge_area_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/000155557797101 DB - PRIME DP - Unbound Medicine ER -