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Lack of the specific influence of histamine and histamine H1, H2 and H3 receptor ligands on the serotonin uptake and release in rat blood platelets.
Pol J Pharmacol. 1996 Nov-Dec; 48(6):615-20.PJ

Abstract

This work was designed to investigate the influence of histamine, and H1 receptor agonist 2-(2-thiazolyl)ethylamine, H2 receptor agonist dimaprit and H3 receptor agonist R-(-)-alpha-methylhistamine on the serotonin uptake and release in rat blood platelets. Histamine and R-(-)-alpha-methylhistamine (up to 1 mmol/l), 2-(2-thiazolyl)ethylamine (up to 10 mumol/l) and dimaprit (up to 1 mumol/l) failed to affect the serotonin uptake. The concentration-dependent inhibitory effects of higher concentrations of 2-(2-thiazolyl)ethylamine and dimaprit (up to 1 mmol/l) were not diminished by the H1 receptor antagonist dimetindene and the H2 receptor antagonist ranitidine (1 and 100 mumol/l each), respectively. Histamine, 2-(2-thiazolyl)ethylamine, dimaprit and R-(-)-alpha-methylhistamine (up to 10 mumol/l) did not change the serotonin release from rat blood platelets. Our results demonstrate that histamine and histamine H1, H2 and H3 receptor agonists do not affect in a specific manner the serotonin uptake and release in rat blood platelets.

Authors+Show Affiliations

Department of Pharmacodynamics, Medical Academy, Białystok, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9112702

Citation

Pawlak, D, et al. "Lack of the Specific Influence of Histamine and Histamine H1, H2 and H3 Receptor Ligands On the Serotonin Uptake and Release in Rat Blood Platelets." Polish Journal of Pharmacology, vol. 48, no. 6, 1996, pp. 615-20.
Pawlak D, Malinowska B, Wollny T, et al. Lack of the specific influence of histamine and histamine H1, H2 and H3 receptor ligands on the serotonin uptake and release in rat blood platelets. Pol J Pharmacol. 1996;48(6):615-20.
Pawlak, D., Malinowska, B., Wollny, T., Godlewski, G., & Buczko, W. (1996). Lack of the specific influence of histamine and histamine H1, H2 and H3 receptor ligands on the serotonin uptake and release in rat blood platelets. Polish Journal of Pharmacology, 48(6), 615-20.
Pawlak D, et al. Lack of the Specific Influence of Histamine and Histamine H1, H2 and H3 Receptor Ligands On the Serotonin Uptake and Release in Rat Blood Platelets. Pol J Pharmacol. 1996 Nov-Dec;48(6):615-20. PubMed PMID: 9112702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of the specific influence of histamine and histamine H1, H2 and H3 receptor ligands on the serotonin uptake and release in rat blood platelets. AU - Pawlak,D, AU - Malinowska,B, AU - Wollny,T, AU - Godlewski,G, AU - Buczko,W, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 615 EP - 20 JF - Polish journal of pharmacology JO - Pol J Pharmacol VL - 48 IS - 6 N2 - This work was designed to investigate the influence of histamine, and H1 receptor agonist 2-(2-thiazolyl)ethylamine, H2 receptor agonist dimaprit and H3 receptor agonist R-(-)-alpha-methylhistamine on the serotonin uptake and release in rat blood platelets. Histamine and R-(-)-alpha-methylhistamine (up to 1 mmol/l), 2-(2-thiazolyl)ethylamine (up to 10 mumol/l) and dimaprit (up to 1 mumol/l) failed to affect the serotonin uptake. The concentration-dependent inhibitory effects of higher concentrations of 2-(2-thiazolyl)ethylamine and dimaprit (up to 1 mmol/l) were not diminished by the H1 receptor antagonist dimetindene and the H2 receptor antagonist ranitidine (1 and 100 mumol/l each), respectively. Histamine, 2-(2-thiazolyl)ethylamine, dimaprit and R-(-)-alpha-methylhistamine (up to 10 mumol/l) did not change the serotonin release from rat blood platelets. Our results demonstrate that histamine and histamine H1, H2 and H3 receptor agonists do not affect in a specific manner the serotonin uptake and release in rat blood platelets. SN - 1230-6002 UR - https://www.unboundmedicine.com/medline/citation/9112702/Lack_of_the_specific_influence_of_histamine_and_histamine_H1_H2_and_H3_receptor_ligands_on_the_serotonin_uptake_and_release_in_rat_blood_platelets_ DB - PRIME DP - Unbound Medicine ER -