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Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia.
J Lab Clin Med. 1977 Sep; 90(3):549-54.JL

Abstract

Zinc administered orally to 12 patients with SCA decreased the mean number of circulating ISC's from 28.0% before treatment to 18.6% during treatment. Seven of the 12 patients had statistically significant individual decreases in ISC counts, and two others had moderate reduction in ISC's of borderline significance. Patients who did not have a significant decrease in ISC count while on zinc therapy had low counts initially. The decrease in ISC's may mean improved oxygenation. The decrease in ISC's provides objective evidence of an in vivo effect of oral zinc treatment in SCA. The role of ISC's in the pathology and symptomatology of SCA is unknown, but some evidence suggests that ISC's may be related to vascular and organ damage. If so, therapies which decrease ISC counts, such as zinc, have the potential of reducing organ damage.

Authors

Brewer GJ
No affiliation info available
Brewer LF
No affiliation info available
Prasad AS
No affiliation info available

MeSH

Administration, OralAdolescentAdultAnemia, Sickle CellErythrocyte CountErythrocytes, AbnormalFemaleHumansMaleZinc

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

911388

Citation

Brewer, G J., et al. "Suppression of Irreversibly Sickled Erythrocytes By Zinc Therapy in Sickle Cell Anemia." The Journal of Laboratory and Clinical Medicine, vol. 90, no. 3, 1977, pp. 549-54.
Brewer GJ, Brewer LF, Prasad AS. Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia. J Lab Clin Med. 1977;90(3):549-54.
Brewer, G. J., Brewer, L. F., & Prasad, A. S. (1977). Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia. The Journal of Laboratory and Clinical Medicine, 90(3), 549-54.
Brewer GJ, Brewer LF, Prasad AS. Suppression of Irreversibly Sickled Erythrocytes By Zinc Therapy in Sickle Cell Anemia. J Lab Clin Med. 1977;90(3):549-54. PubMed PMID: 911388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia. AU - Brewer,G J, AU - Brewer,L F, AU - Prasad,A S, PY - 1977/9/1/pubmed PY - 1977/9/1/medline PY - 1977/9/1/entrez SP - 549 EP - 54 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 90 IS - 3 N2 - Zinc administered orally to 12 patients with SCA decreased the mean number of circulating ISC's from 28.0% before treatment to 18.6% during treatment. Seven of the 12 patients had statistically significant individual decreases in ISC counts, and two others had moderate reduction in ISC's of borderline significance. Patients who did not have a significant decrease in ISC count while on zinc therapy had low counts initially. The decrease in ISC's may mean improved oxygenation. The decrease in ISC's provides objective evidence of an in vivo effect of oral zinc treatment in SCA. The role of ISC's in the pathology and symptomatology of SCA is unknown, but some evidence suggests that ISC's may be related to vascular and organ damage. If so, therapies which decrease ISC counts, such as zinc, have the potential of reducing organ damage. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/911388/Suppression_of_irreversibly_sickled_erythrocytes_by_zinc_therapy_in_sickle_cell_anemia_ L2 - https://www.diseaseinfosearch.org/result/6589 DB - PRIME DP - Unbound Medicine ER -