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[Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area].
Gastroenterol Clin Biol 1996; 20(11):931-7GC

Abstract

OBJECTIVES

Circulating IgA class anti-endomysium and anti-reticulin antibodies are reliable serological markers for the diagnosis of coeliac disease. The aim of this study was to evaluate their diagnostic sensitivity and specificity, and their prevalence in a group of coeliac adults taking a gluten-free diet followed in Ile-de-France.

METHODS

One hundred and forty-five sera from 134 patients were examined for IgA and IgG anti-endomysium and anti-reticulin antibodies by indirect immunofluorescence. Sixty-eight patients were confirmed coeliacs; 8 patients with noncoeliac (unresponsive to a gluten-free diet) duodenal villous atrophy and 58 patients with no villous atrophy served as controls.

RESULTS

In active coeliac disease, the sensitivity of anti-endomysium and anti-reticulin antibodies was 88% and 50%, respectively. Their specificity was 100%: they were never detected in case of noncoeliac villous atrophy. Under a strict gluten-free diet, their prevalence was 7% and 0%, respectively.

CONCLUSION

In the studied population, the diagnosis accuracy of IgA anti-endomysium antibodies confirms their usefulness in screening and follow-up of coeliac disease. The absence of anti-endomysium and anti-reticulin antibodies in those cases with noncoeliac villous atrophy suggests that in the latter, different immunopathologic mechanisms, as compared with coeliac disease, are concerned.

Authors+Show Affiliations

Service d'Hépato-Gastroentérologie, Hôpital Saint-Louis, Paris.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

9119181

Citation

Boige, V, et al. "[Anti-endomysium and Anti-reticulin Antibodies in Adults With Celiac Disease Followed-up in the Paris Area]." Gastroenterologie Clinique Et Biologique, vol. 20, no. 11, 1996, pp. 931-7.
Boige V, Bouhnik Y, Delchier JC, et al. [Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area]. Gastroenterol Clin Biol. 1996;20(11):931-7.
Boige, V., Bouhnik, Y., Delchier, J. C., Jian, R., Matuchansky, C., & André, C. (1996). [Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area]. Gastroenterologie Clinique Et Biologique, 20(11), pp. 931-7.
Boige V, et al. [Anti-endomysium and Anti-reticulin Antibodies in Adults With Celiac Disease Followed-up in the Paris Area]. Gastroenterol Clin Biol. 1996;20(11):931-7. PubMed PMID: 9119181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area]. AU - Boige,V, AU - Bouhnik,Y, AU - Delchier,J C, AU - Jian,R, AU - Matuchansky,C, AU - André,C, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 931 EP - 7 JF - Gastroenterologie clinique et biologique JO - Gastroenterol. Clin. Biol. VL - 20 IS - 11 N2 - OBJECTIVES: Circulating IgA class anti-endomysium and anti-reticulin antibodies are reliable serological markers for the diagnosis of coeliac disease. The aim of this study was to evaluate their diagnostic sensitivity and specificity, and their prevalence in a group of coeliac adults taking a gluten-free diet followed in Ile-de-France. METHODS: One hundred and forty-five sera from 134 patients were examined for IgA and IgG anti-endomysium and anti-reticulin antibodies by indirect immunofluorescence. Sixty-eight patients were confirmed coeliacs; 8 patients with noncoeliac (unresponsive to a gluten-free diet) duodenal villous atrophy and 58 patients with no villous atrophy served as controls. RESULTS: In active coeliac disease, the sensitivity of anti-endomysium and anti-reticulin antibodies was 88% and 50%, respectively. Their specificity was 100%: they were never detected in case of noncoeliac villous atrophy. Under a strict gluten-free diet, their prevalence was 7% and 0%, respectively. CONCLUSION: In the studied population, the diagnosis accuracy of IgA anti-endomysium antibodies confirms their usefulness in screening and follow-up of coeliac disease. The absence of anti-endomysium and anti-reticulin antibodies in those cases with noncoeliac villous atrophy suggests that in the latter, different immunopathologic mechanisms, as compared with coeliac disease, are concerned. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/9119181/[Anti_endomysium_and_anti_reticulin_antibodies_in_adults_with_celiac_disease_followed_up_in_the_Paris_area]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -