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[Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area].

Abstract

OBJECTIVES

Circulating IgA class anti-endomysium and anti-reticulin antibodies are reliable serological markers for the diagnosis of coeliac disease. The aim of this study was to evaluate their diagnostic sensitivity and specificity, and their prevalence in a group of coeliac adults taking a gluten-free diet followed in Ile-de-France.

METHODS

One hundred and forty-five sera from 134 patients were examined for IgA and IgG anti-endomysium and anti-reticulin antibodies by indirect immunofluorescence. Sixty-eight patients were confirmed coeliacs; 8 patients with noncoeliac (unresponsive to a gluten-free diet) duodenal villous atrophy and 58 patients with no villous atrophy served as controls.

RESULTS

In active coeliac disease, the sensitivity of anti-endomysium and anti-reticulin antibodies was 88% and 50%, respectively. Their specificity was 100%: they were never detected in case of noncoeliac villous atrophy. Under a strict gluten-free diet, their prevalence was 7% and 0%, respectively.

CONCLUSION

In the studied population, the diagnosis accuracy of IgA anti-endomysium antibodies confirms their usefulness in screening and follow-up of coeliac disease. The absence of anti-endomysium and anti-reticulin antibodies in those cases with noncoeliac villous atrophy suggests that in the latter, different immunopathologic mechanisms, as compared with coeliac disease, are concerned.

Authors+Show Affiliations

,

Service d'Hépato-Gastroentérologie, Hôpital Saint-Louis, Paris.

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Source

MeSH

Adolescent
Adult
Aged
Aged, 80 and over
Antibodies
Biomarkers
Celiac Disease
Female
Fluorescent Antibody Technique, Indirect
Follow-Up Studies
Humans
Immunoglobulin A
Male
Middle Aged
Paris
Predictive Value of Tests
Reticulin
Sensitivity and Specificity

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

9119181

Citation

Boige, V, et al. "[Anti-endomysium and Anti-reticulin Antibodies in Adults With Celiac Disease Followed-up in the Paris Area]." Gastroenterologie Clinique Et Biologique, vol. 20, no. 11, 1996, pp. 931-7.
Boige V, Bouhnik Y, Delchier JC, et al. [Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area]. Gastroenterol Clin Biol. 1996;20(11):931-7.
Boige, V., Bouhnik, Y., Delchier, J. C., Jian, R., Matuchansky, C., & André, C. (1996). [Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area]. Gastroenterologie Clinique Et Biologique, 20(11), pp. 931-7.
Boige V, et al. [Anti-endomysium and Anti-reticulin Antibodies in Adults With Celiac Disease Followed-up in the Paris Area]. Gastroenterol Clin Biol. 1996;20(11):931-7. PubMed PMID: 9119181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-endomysium and anti-reticulin antibodies in adults with celiac disease followed-up in the Paris area]. AU - Boige,V, AU - Bouhnik,Y, AU - Delchier,J C, AU - Jian,R, AU - Matuchansky,C, AU - André,C, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 931 EP - 7 JF - Gastroenterologie clinique et biologique JO - Gastroenterol. Clin. Biol. VL - 20 IS - 11 N2 - OBJECTIVES: Circulating IgA class anti-endomysium and anti-reticulin antibodies are reliable serological markers for the diagnosis of coeliac disease. The aim of this study was to evaluate their diagnostic sensitivity and specificity, and their prevalence in a group of coeliac adults taking a gluten-free diet followed in Ile-de-France. METHODS: One hundred and forty-five sera from 134 patients were examined for IgA and IgG anti-endomysium and anti-reticulin antibodies by indirect immunofluorescence. Sixty-eight patients were confirmed coeliacs; 8 patients with noncoeliac (unresponsive to a gluten-free diet) duodenal villous atrophy and 58 patients with no villous atrophy served as controls. RESULTS: In active coeliac disease, the sensitivity of anti-endomysium and anti-reticulin antibodies was 88% and 50%, respectively. Their specificity was 100%: they were never detected in case of noncoeliac villous atrophy. Under a strict gluten-free diet, their prevalence was 7% and 0%, respectively. CONCLUSION: In the studied population, the diagnosis accuracy of IgA anti-endomysium antibodies confirms their usefulness in screening and follow-up of coeliac disease. The absence of anti-endomysium and anti-reticulin antibodies in those cases with noncoeliac villous atrophy suggests that in the latter, different immunopathologic mechanisms, as compared with coeliac disease, are concerned. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/9119181/[Anti_endomysium_and_anti_reticulin_antibodies_in_adults_with_celiac_disease_followed_up_in_the_Paris_area]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -