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Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts.
Nutr Cancer 1997; 27(2):162-8NC

Abstract

These studies examined the ability of garlic powder or allyl sulfur compounds to modify selenite protection against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary epithelial cell DNA adducts. In Study 1, female rats (n = 5) were fed diets containing sodium selenite at 0.1, 0.5, or 1.0 mg Se/kg and garlic powder at 0, 20, or 40 g/kg diet. Total DNA adducts correlated inversely with selenite or garlic powder intake. Garlic powder enhanced the selenite inhibition of mammary DNA adducts. In Study 2, selenite (2.0 mg Se/kg diet), garlic powder (20 g/kg diet), water-soluble S-allyl cysteine (SAC; 5.2 mumol/kg diet), and oil-soluble diallyl disulfide (DADS; 5.2 mumol/kg diet) inhibited (p < 0.05) total DNA adducts by 45%, 40%, 80%, and 75%, respectively. Combining selenite with garlic powder, SAC, or DADS further inhibited DNA adducts. Selenite, but not garlic powder, SAC, or DADS, enhanced liver glutathione S-transferase and uridine diphosphate-glucuronosyltransferase activities. Selenite, garlic powder, SAC, or DADS did not affect liver cytochrome P-450 1A1 activities. The present studies provide evidence that synergistic protection against the initiation of DMBA carcinogenesis occurs when selenite is supplemented in conjunction with garlic or its allyl sulfur components.

Authors+Show Affiliations

Department of Nutrition, Pennsylvania State University, University Park 16802, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9121944

Citation

Schaffer, E M., et al. "Garlic Powder and Allyl Sulfur Compounds Enhance the Ability of Dietary Selenite to Inhibit 7,12-dimethylbenz[a]anthracene-induced Mammary DNA Adducts." Nutrition and Cancer, vol. 27, no. 2, 1997, pp. 162-8.
Schaffer EM, Liu JZ, Milner JA. Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. Nutr Cancer. 1997;27(2):162-8.
Schaffer, E. M., Liu, J. Z., & Milner, J. A. (1997). Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. Nutrition and Cancer, 27(2), pp. 162-8.
Schaffer EM, Liu JZ, Milner JA. Garlic Powder and Allyl Sulfur Compounds Enhance the Ability of Dietary Selenite to Inhibit 7,12-dimethylbenz[a]anthracene-induced Mammary DNA Adducts. Nutr Cancer. 1997;27(2):162-8. PubMed PMID: 9121944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. AU - Schaffer,E M, AU - Liu,J Z, AU - Milner,J A, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 162 EP - 8 JF - Nutrition and cancer JO - Nutr Cancer VL - 27 IS - 2 N2 - These studies examined the ability of garlic powder or allyl sulfur compounds to modify selenite protection against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary epithelial cell DNA adducts. In Study 1, female rats (n = 5) were fed diets containing sodium selenite at 0.1, 0.5, or 1.0 mg Se/kg and garlic powder at 0, 20, or 40 g/kg diet. Total DNA adducts correlated inversely with selenite or garlic powder intake. Garlic powder enhanced the selenite inhibition of mammary DNA adducts. In Study 2, selenite (2.0 mg Se/kg diet), garlic powder (20 g/kg diet), water-soluble S-allyl cysteine (SAC; 5.2 mumol/kg diet), and oil-soluble diallyl disulfide (DADS; 5.2 mumol/kg diet) inhibited (p < 0.05) total DNA adducts by 45%, 40%, 80%, and 75%, respectively. Combining selenite with garlic powder, SAC, or DADS further inhibited DNA adducts. Selenite, but not garlic powder, SAC, or DADS, enhanced liver glutathione S-transferase and uridine diphosphate-glucuronosyltransferase activities. Selenite, garlic powder, SAC, or DADS did not affect liver cytochrome P-450 1A1 activities. The present studies provide evidence that synergistic protection against the initiation of DMBA carcinogenesis occurs when selenite is supplemented in conjunction with garlic or its allyl sulfur components. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/9121944/Garlic_powder_and_allyl_sulfur_compounds_enhance_the_ability_of_dietary_selenite_to_inhibit_712_dimethylbenz[a]anthracene_induced_mammary_DNA_adducts_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635589709514519 DB - PRIME DP - Unbound Medicine ER -