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Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts.

Abstract

These studies examined the ability of garlic powder or allyl sulfur compounds to modify selenite protection against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary epithelial cell DNA adducts. In Study 1, female rats (n = 5) were fed diets containing sodium selenite at 0.1, 0.5, or 1.0 mg Se/kg and garlic powder at 0, 20, or 40 g/kg diet. Total DNA adducts correlated inversely with selenite or garlic powder intake. Garlic powder enhanced the selenite inhibition of mammary DNA adducts. In Study 2, selenite (2.0 mg Se/kg diet), garlic powder (20 g/kg diet), water-soluble S-allyl cysteine (SAC; 5.2 mumol/kg diet), and oil-soluble diallyl disulfide (DADS; 5.2 mumol/kg diet) inhibited (p < 0.05) total DNA adducts by 45%, 40%, 80%, and 75%, respectively. Combining selenite with garlic powder, SAC, or DADS further inhibited DNA adducts. Selenite, but not garlic powder, SAC, or DADS, enhanced liver glutathione S-transferase and uridine diphosphate-glucuronosyltransferase activities. Selenite, garlic powder, SAC, or DADS did not affect liver cytochrome P-450 1A1 activities. The present studies provide evidence that synergistic protection against the initiation of DMBA carcinogenesis occurs when selenite is supplemented in conjunction with garlic or its allyl sulfur components.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Pennsylvania State University, University Park 16802, USA.

    ,

    Source

    Nutrition and cancer 27:2 1997 pg 162-8

    MeSH

    9,10-Dimethyl-1,2-benzanthracene
    Allyl Compounds
    Animals
    Antineoplastic Agents
    Carcinogens
    Cysteine
    DNA Adducts
    Disulfides
    Drug Interactions
    Epithelium
    Female
    Garlic
    Glucuronosyltransferase
    Glutathione Transferase
    Mammary Glands, Animal
    Plants, Medicinal
    Rats
    Rats, Sprague-Dawley
    Sodium Selenite

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9121944

    Citation

    Schaffer, E M., et al. "Garlic Powder and Allyl Sulfur Compounds Enhance the Ability of Dietary Selenite to Inhibit 7,12-dimethylbenz[a]anthracene-induced Mammary DNA Adducts." Nutrition and Cancer, vol. 27, no. 2, 1997, pp. 162-8.
    Schaffer EM, Liu JZ, Milner JA. Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. Nutr Cancer. 1997;27(2):162-8.
    Schaffer, E. M., Liu, J. Z., & Milner, J. A. (1997). Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. Nutrition and Cancer, 27(2), pp. 162-8.
    Schaffer EM, Liu JZ, Milner JA. Garlic Powder and Allyl Sulfur Compounds Enhance the Ability of Dietary Selenite to Inhibit 7,12-dimethylbenz[a]anthracene-induced Mammary DNA Adducts. Nutr Cancer. 1997;27(2):162-8. PubMed PMID: 9121944.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Garlic powder and allyl sulfur compounds enhance the ability of dietary selenite to inhibit 7,12-dimethylbenz[a]anthracene-induced mammary DNA adducts. AU - Schaffer,E M, AU - Liu,J Z, AU - Milner,J A, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 162 EP - 8 JF - Nutrition and cancer JO - Nutr Cancer VL - 27 IS - 2 N2 - These studies examined the ability of garlic powder or allyl sulfur compounds to modify selenite protection against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary epithelial cell DNA adducts. In Study 1, female rats (n = 5) were fed diets containing sodium selenite at 0.1, 0.5, or 1.0 mg Se/kg and garlic powder at 0, 20, or 40 g/kg diet. Total DNA adducts correlated inversely with selenite or garlic powder intake. Garlic powder enhanced the selenite inhibition of mammary DNA adducts. In Study 2, selenite (2.0 mg Se/kg diet), garlic powder (20 g/kg diet), water-soluble S-allyl cysteine (SAC; 5.2 mumol/kg diet), and oil-soluble diallyl disulfide (DADS; 5.2 mumol/kg diet) inhibited (p < 0.05) total DNA adducts by 45%, 40%, 80%, and 75%, respectively. Combining selenite with garlic powder, SAC, or DADS further inhibited DNA adducts. Selenite, but not garlic powder, SAC, or DADS, enhanced liver glutathione S-transferase and uridine diphosphate-glucuronosyltransferase activities. Selenite, garlic powder, SAC, or DADS did not affect liver cytochrome P-450 1A1 activities. The present studies provide evidence that synergistic protection against the initiation of DMBA carcinogenesis occurs when selenite is supplemented in conjunction with garlic or its allyl sulfur components. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/9121944/Garlic_powder_and_allyl_sulfur_compounds_enhance_the_ability_of_dietary_selenite_to_inhibit_712_dimethylbenz[a]anthracene_induced_mammary_DNA_adducts_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635589709514519 DB - PRIME DP - Unbound Medicine ER -