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Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus.
AJR Am J Roentgenol 1997; 168(4):1045-50AA

Abstract

OBJECTIVE

An outbreak of Sauropus androgynus-associated bronchiolitis obliterans occurred in Taiwan in the summer of 1995. We undertook a study of the correlation between high-resolution CT findings and pulmonary function testing in patients from this outbreak.

MATERIALS AND METHODS

We evaluated inspiratory-expiratory high-resolution CT scans of 24 patients with S. androgynus-associated bronchiolitis obliterans. The presence of bronchiectasis was assessed by two visual scores (a bronchial dilatation score and a bronchiectasis extent score). Extent of air-trapping was assessed visually and given a score. We also used computer software to assess the extent of air-trapping and generate scores of dynamic attenuation. Spirometry, plethysmography, and diffusion capacity of each patient were also obtained.

RESULTS

All four scores had statistically significant correlation with forced expiratory volume in 1 sec (FEV1) (p < .05 for both bronchiectasis scores; p < .001 for both air-trapping scores). The two air-trapping scores had statistically significant correlation with forced vital capacity and diffusion capacity. We found the scores for dynamic attenuation had the greatest correlation with FEV1 (r = .85). We also found that mosaic attenuation was notable on expiratory CT scans alone in nine patients (type 1 air-trapping) and on both inspiratory and expiratory CT scans in 15 patients (type 2 air-trapping). In the latter group, FEV1 was significantly lower (p < .01).

CONCLUSION

Findings from high-resolution CT of air-trapping were more important than findings of bronchiectasis when correlating pulmonary function with S. androgynus-associated bronchiolitis obliterans. Type 2 air-trapping suggested a more severe air-flow obstruction than did type 1. Scores for quantitative attenuation generated by computer software were helpful in assessing air-trapping and correlating it with pulmonary function. These findings may apply to patients with bronchiolitis obliterans from other causes.

Authors+Show Affiliations

Department of Radiology, Veterans General Hospital-Kaohsiung, Taiwan ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9124113

Citation

Yang, C F., et al. "Correlation of High-resolution CT and Pulmonary Function in Bronchiolitis Obliterans: a Study Based On 24 Patients Associated With Consumption of Sauropus Androgynus." AJR. American Journal of Roentgenology, vol. 168, no. 4, 1997, pp. 1045-50.
Yang CF, Wu MT, Chiang AA, et al. Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus. AJR Am J Roentgenol. 1997;168(4):1045-50.
Yang, C. F., Wu, M. T., Chiang, A. A., Lai, R. S., Chen, C., Tiao, W. M., ... Pan, H. B. (1997). Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus. AJR. American Journal of Roentgenology, 168(4), pp. 1045-50.
Yang CF, et al. Correlation of High-resolution CT and Pulmonary Function in Bronchiolitis Obliterans: a Study Based On 24 Patients Associated With Consumption of Sauropus Androgynus. AJR Am J Roentgenol. 1997;168(4):1045-50. PubMed PMID: 9124113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus. AU - Yang,C F, AU - Wu,M T, AU - Chiang,A A, AU - Lai,R S, AU - Chen,C, AU - Tiao,W M, AU - McLoud,T C, AU - Wang,J S, AU - Pan,H B, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 1045 EP - 50 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 168 IS - 4 N2 - OBJECTIVE: An outbreak of Sauropus androgynus-associated bronchiolitis obliterans occurred in Taiwan in the summer of 1995. We undertook a study of the correlation between high-resolution CT findings and pulmonary function testing in patients from this outbreak. MATERIALS AND METHODS: We evaluated inspiratory-expiratory high-resolution CT scans of 24 patients with S. androgynus-associated bronchiolitis obliterans. The presence of bronchiectasis was assessed by two visual scores (a bronchial dilatation score and a bronchiectasis extent score). Extent of air-trapping was assessed visually and given a score. We also used computer software to assess the extent of air-trapping and generate scores of dynamic attenuation. Spirometry, plethysmography, and diffusion capacity of each patient were also obtained. RESULTS: All four scores had statistically significant correlation with forced expiratory volume in 1 sec (FEV1) (p < .05 for both bronchiectasis scores; p < .001 for both air-trapping scores). The two air-trapping scores had statistically significant correlation with forced vital capacity and diffusion capacity. We found the scores for dynamic attenuation had the greatest correlation with FEV1 (r = .85). We also found that mosaic attenuation was notable on expiratory CT scans alone in nine patients (type 1 air-trapping) and on both inspiratory and expiratory CT scans in 15 patients (type 2 air-trapping). In the latter group, FEV1 was significantly lower (p < .01). CONCLUSION: Findings from high-resolution CT of air-trapping were more important than findings of bronchiectasis when correlating pulmonary function with S. androgynus-associated bronchiolitis obliterans. Type 2 air-trapping suggested a more severe air-flow obstruction than did type 1. Scores for quantitative attenuation generated by computer software were helpful in assessing air-trapping and correlating it with pulmonary function. These findings may apply to patients with bronchiolitis obliterans from other causes. SN - 0361-803X UR - https://www.unboundmedicine.com/medline/citation/9124113/Correlation_of_high_resolution_CT_and_pulmonary_function_in_bronchiolitis_obliterans:_a_study_based_on_24_patients_associated_with_consumption_of_Sauropus_androgynus_ L2 - http://www.ajronline.org/doi/full/10.2214/ajr.168.4.9124113 DB - PRIME DP - Unbound Medicine ER -