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Effect of dietary fish oil supplementation on peroxidation of serum lipids in patients with non-insulin dependent diabetes mellitus.
Atherosclerosis. 1996 Apr 05; 121(2):275-83.A

Abstract

Lipid peroxidation may be important in the development of cardiovascular disease, a common cause of mortality and morbidity in non-insulin dependent diabetes mellitus (NIDDM). We assessed the degree of lipid peroxidation by measuring plasma malondialdehyde, as thiobarbituric acid reacting substances (TBARS), in 23 non-insulin diabetic patients. Plasma levels of standardised alpha-tocopherol (vitamin E), lipid content of whole plasma and lipoprotein fractions, glycosylated haemoglobin, glycosylated low density lipoprotein (LDL) and fasting blood glucose were also measured. On completion of the baseline studies patients randomly received either fish oil or matching olive oil capsules in a double blind crossover fashion for 6 weeks followed by a 6 week washout period and a final 6 week treatment phase. Studies, identical to the initial baseline studies, were performed at the end of the of the active treatment periods at 6 and 18 weeks. Treatment with olive oil did not change levels of TBARS, vitamin E or indices of glycaemic control compared with baseline. Total cholesterol and triglyceride (TG) content of plasma and lipoprotein fractions were not significantly altered. Treatment with fish oil resulted in elevation of TBARS (P < 0.001) and reduction of vitamin E (P < 0.01) compared with baseline and olive oil treatment. Plasma cholesterol was unchanged. A reduction in plasma TG compared with baseline occurred but failed to reach significance (P =0.07). Changes in apo B containing lipoproteins induced by fish oil failed to reach significance. No significant changes were observed in concentration or composition of high density lipoprotein (HDL). Fish oil treatment showed no change in glycaemic control as assessed by glycosylated haemoglobin and LDL although a rise in fasting blood glucose just failed to reach significance (P = 0.06). Lipid peroxidation in NIDDM can be exacerbated by dietary fish oil. This potentially adverse reaction may limit the therapeutic use of fish oils in such patients.

Authors+Show Affiliations

Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Belfast, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9125301

Citation

McGrath, L T., et al. "Effect of Dietary Fish Oil Supplementation On Peroxidation of Serum Lipids in Patients With Non-insulin Dependent Diabetes Mellitus." Atherosclerosis, vol. 121, no. 2, 1996, pp. 275-83.
McGrath LT, Brennan GM, Donnelly JP, et al. Effect of dietary fish oil supplementation on peroxidation of serum lipids in patients with non-insulin dependent diabetes mellitus. Atherosclerosis. 1996;121(2):275-83.
McGrath, L. T., Brennan, G. M., Donnelly, J. P., Johnston, G. D., Hayes, J. R., & McVeigh, G. E. (1996). Effect of dietary fish oil supplementation on peroxidation of serum lipids in patients with non-insulin dependent diabetes mellitus. Atherosclerosis, 121(2), 275-83.
McGrath LT, et al. Effect of Dietary Fish Oil Supplementation On Peroxidation of Serum Lipids in Patients With Non-insulin Dependent Diabetes Mellitus. Atherosclerosis. 1996 Apr 5;121(2):275-83. PubMed PMID: 9125301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fish oil supplementation on peroxidation of serum lipids in patients with non-insulin dependent diabetes mellitus. AU - McGrath,L T, AU - Brennan,G M, AU - Donnelly,J P, AU - Johnston,G D, AU - Hayes,J R, AU - McVeigh,G E, PY - 1996/4/5/pubmed PY - 1996/4/5/medline PY - 1996/4/5/entrez SP - 275 EP - 83 JF - Atherosclerosis JO - Atherosclerosis VL - 121 IS - 2 N2 - Lipid peroxidation may be important in the development of cardiovascular disease, a common cause of mortality and morbidity in non-insulin dependent diabetes mellitus (NIDDM). We assessed the degree of lipid peroxidation by measuring plasma malondialdehyde, as thiobarbituric acid reacting substances (TBARS), in 23 non-insulin diabetic patients. Plasma levels of standardised alpha-tocopherol (vitamin E), lipid content of whole plasma and lipoprotein fractions, glycosylated haemoglobin, glycosylated low density lipoprotein (LDL) and fasting blood glucose were also measured. On completion of the baseline studies patients randomly received either fish oil or matching olive oil capsules in a double blind crossover fashion for 6 weeks followed by a 6 week washout period and a final 6 week treatment phase. Studies, identical to the initial baseline studies, were performed at the end of the of the active treatment periods at 6 and 18 weeks. Treatment with olive oil did not change levels of TBARS, vitamin E or indices of glycaemic control compared with baseline. Total cholesterol and triglyceride (TG) content of plasma and lipoprotein fractions were not significantly altered. Treatment with fish oil resulted in elevation of TBARS (P < 0.001) and reduction of vitamin E (P < 0.01) compared with baseline and olive oil treatment. Plasma cholesterol was unchanged. A reduction in plasma TG compared with baseline occurred but failed to reach significance (P =0.07). Changes in apo B containing lipoproteins induced by fish oil failed to reach significance. No significant changes were observed in concentration or composition of high density lipoprotein (HDL). Fish oil treatment showed no change in glycaemic control as assessed by glycosylated haemoglobin and LDL although a rise in fasting blood glucose just failed to reach significance (P = 0.06). Lipid peroxidation in NIDDM can be exacerbated by dietary fish oil. This potentially adverse reaction may limit the therapeutic use of fish oils in such patients. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/9125301/Effect_of_dietary_fish_oil_supplementation_on_peroxidation_of_serum_lipids_in_patients_with_non_insulin_dependent_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0021-9150(95)05741-2 DB - PRIME DP - Unbound Medicine ER -