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Lewy bodies and progressive dementia: a critical review and meta-analysis.
J Int Neuropsychol Soc. 1997 Mar; 3(2):179-94.JI

Abstract

Researchers disagree as to whether Lewy body disease (LBD) constitutes a variant of Alzheimer's (AD) or Parkinson's disease (PD), or alternatively, whether it is an independent disease process. The neuropathological, genetic, and clinical characteristics of LBD are reviewed and compared to those of AD and PD. Data for 150 cases of LBD reported in the literature were compiled and grouped according to neuropathological status. Patients with pure LBD (with limited or no concurrent AD pathology) tend to present at a younger age with extrapyramidal signs followed by dementia, whereas patients with mixed LBD-AD (concurrent LB and AD pathology) are somewhat older and tend to present with dementia. The cognitive profile of LBD patients, and the relationships among LBD, AD, and PD remain unclear due to methodological limitations and the paucity of studies comparing the groups directly.

Authors+Show Affiliations

The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9126859

Citation

Cercy, S P., and F W. Bylsma. "Lewy Bodies and Progressive Dementia: a Critical Review and Meta-analysis." Journal of the International Neuropsychological Society : JINS, vol. 3, no. 2, 1997, pp. 179-94.
Cercy SP, Bylsma FW. Lewy bodies and progressive dementia: a critical review and meta-analysis. J Int Neuropsychol Soc. 1997;3(2):179-94.
Cercy, S. P., & Bylsma, F. W. (1997). Lewy bodies and progressive dementia: a critical review and meta-analysis. Journal of the International Neuropsychological Society : JINS, 3(2), 179-94.
Cercy SP, Bylsma FW. Lewy Bodies and Progressive Dementia: a Critical Review and Meta-analysis. J Int Neuropsychol Soc. 1997;3(2):179-94. PubMed PMID: 9126859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lewy bodies and progressive dementia: a critical review and meta-analysis. AU - Cercy,S P, AU - Bylsma,F W, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 179 EP - 94 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 3 IS - 2 N2 - Researchers disagree as to whether Lewy body disease (LBD) constitutes a variant of Alzheimer's (AD) or Parkinson's disease (PD), or alternatively, whether it is an independent disease process. The neuropathological, genetic, and clinical characteristics of LBD are reviewed and compared to those of AD and PD. Data for 150 cases of LBD reported in the literature were compiled and grouped according to neuropathological status. Patients with pure LBD (with limited or no concurrent AD pathology) tend to present at a younger age with extrapyramidal signs followed by dementia, whereas patients with mixed LBD-AD (concurrent LB and AD pathology) are somewhat older and tend to present with dementia. The cognitive profile of LBD patients, and the relationships among LBD, AD, and PD remain unclear due to methodological limitations and the paucity of studies comparing the groups directly. SN - 1355-6177 UR - https://www.unboundmedicine.com/medline/citation/9126859/Lewy_bodies_and_progressive_dementia:_a_critical_review_and_meta_analysis_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -