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Receiver operating characteristic (ROC) curve analysis of the tumor markers CEA, CA 19-9 and CA 72-4 in gastric cancer.
Int Surg. 1996 Oct-Dec; 81(4):400-2.IS

Abstract

Pre-surgery serum levels of CA 72-4, CEA and CA 19-9 were quantified by the enzyme immunoassay method in 167 patients with histological diagnosis of gastric adenocarcinoma and in 92 patients with an endoscopic diagnosis of benign gastric pathology. CA 72-4 showed a better correlation between its serum levels and the different clinical stages of the disease than CEA and CA 19-9. At the individual study of stages I-II, CA 72-4 proved positive in 36.9% of patients while CEA and CA 19-9 appeared positive in 10.8% and 8.6%, respectively. In the ROC curve, at a specificity of 95%, the sensitivities of CA 72-4, CEA and CA 19-9 were 59.8%, 21% and 26.3% respectively. The discriminatory capacity of the test (area under the ROC curve +/- SD) was 0.86 +/- 0.03 in the case of CA 72-4, 0.52 +/- 0.03 for CEA and 0.58 +/- 0.03 for CA 19-9. In conclusion, in our series and with regard to CEA and CA 19-9, CA 72-4 shows better sensitivity and discriminatory capacity. CEA and CA 19-9 do not provide significant benefits when combined with CA 72-4 due to the good results obtained with the later marker alone.

Authors+Show Affiliations

Department of Surgery, Hospital General del Insalud, Soria, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9127805

Citation

Fernández-Fernández, L, et al. "Receiver Operating Characteristic (ROC) Curve Analysis of the Tumor Markers CEA, CA 19-9 and CA 72-4 in Gastric Cancer." International Surgery, vol. 81, no. 4, 1996, pp. 400-2.
Fernández-Fernández L, Tejero E, Tieso A, et al. Receiver operating characteristic (ROC) curve analysis of the tumor markers CEA, CA 19-9 and CA 72-4 in gastric cancer. Int Surg. 1996;81(4):400-2.
Fernández-Fernández, L., Tejero, E., Tieso, A., Rabadán, L., Munoz, M., & Santos, I. (1996). Receiver operating characteristic (ROC) curve analysis of the tumor markers CEA, CA 19-9 and CA 72-4 in gastric cancer. International Surgery, 81(4), 400-2.
Fernández-Fernández L, et al. Receiver Operating Characteristic (ROC) Curve Analysis of the Tumor Markers CEA, CA 19-9 and CA 72-4 in Gastric Cancer. Int Surg. 1996 Oct-Dec;81(4):400-2. PubMed PMID: 9127805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Receiver operating characteristic (ROC) curve analysis of the tumor markers CEA, CA 19-9 and CA 72-4 in gastric cancer. AU - Fernández-Fernández,L, AU - Tejero,E, AU - Tieso,A, AU - Rabadán,L, AU - Munoz,M, AU - Santos,I, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 400 EP - 2 JF - International surgery JO - Int Surg VL - 81 IS - 4 N2 - Pre-surgery serum levels of CA 72-4, CEA and CA 19-9 were quantified by the enzyme immunoassay method in 167 patients with histological diagnosis of gastric adenocarcinoma and in 92 patients with an endoscopic diagnosis of benign gastric pathology. CA 72-4 showed a better correlation between its serum levels and the different clinical stages of the disease than CEA and CA 19-9. At the individual study of stages I-II, CA 72-4 proved positive in 36.9% of patients while CEA and CA 19-9 appeared positive in 10.8% and 8.6%, respectively. In the ROC curve, at a specificity of 95%, the sensitivities of CA 72-4, CEA and CA 19-9 were 59.8%, 21% and 26.3% respectively. The discriminatory capacity of the test (area under the ROC curve +/- SD) was 0.86 +/- 0.03 in the case of CA 72-4, 0.52 +/- 0.03 for CEA and 0.58 +/- 0.03 for CA 19-9. In conclusion, in our series and with regard to CEA and CA 19-9, CA 72-4 shows better sensitivity and discriminatory capacity. CEA and CA 19-9 do not provide significant benefits when combined with CA 72-4 due to the good results obtained with the later marker alone. SN - 0020-8868 UR - https://www.unboundmedicine.com/medline/citation/9127805/Receiver_operating_characteristic__ROC__curve_analysis_of_the_tumor_markers_CEA_CA_19_9_and_CA_72_4_in_gastric_cancer_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -