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Efficacy of omeprazole one year after cure of Helicobacter pylori infection in duodenal ulcer patients.
Am J Gastroenterol. 1997 Apr; 92(4):576-81.AJ

Abstract

OBJECTIVE

We have previously shown that, in duodenal ulcer patients, pH control by omeprazole is less pronounced after cure of Helicobacter pylori infection. The present study was designed to test the hypothesis that this response to omeprazole persists 1 yr after cure of H. pylori infection.

METHODS

In 12 duodenal ulcer patients, intragastric acidity was measured with a glass electrode during treatment with omeprazole (20 mg) once daily before, and 4-6 wk and 1 yr after, cure of H. pylori infection. H. pylori infection was assessed by [13C]urea breath test, culture, histology (Warthin Starry stain), and rapid urease test.

RESULTS

Cure of H. pylori infection resulted in a lowered pH during omeprazole treatment. This effect persisted after 1 yr. Median 24-h gastric pH before H. pylori treatment was 5.6; 4-6 wk after cure of the infection it was 2.9 (p = 0.003), and 1 yr after cure of the infection it remained unchanged (pH = 2.5; p = 0.5). Accordingly, twice as much time was spent above pH 3 and pH 4 before H. pylori treatment than 1 or 12 months after cure (percent of time > or = pH 3: 82.7 vs. 49.7 vs. 43.1; percent of time > or = pH 4: 72.7 vs. 38.3 vs. 26.4).

CONCLUSION

In duodenal ulcer patients, cure of H. pylori infection resulted in a marked rapid and persistent decrease of the pH increasing effect of omeprazole. Therefore, H. pylori is a determinant of the pH achieved in response to omeprazole treatment in duodenal ulcer patients.

Authors+Show Affiliations

Department of Internal Medicine and Gastroenterology, Elisabeth Hospital Essen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9128302

Citation

Labenz, J, et al. "Efficacy of Omeprazole One Year After Cure of Helicobacter Pylori Infection in Duodenal Ulcer Patients." The American Journal of Gastroenterology, vol. 92, no. 4, 1997, pp. 576-81.
Labenz J, Tillenburg B, Peitz U, et al. Efficacy of omeprazole one year after cure of Helicobacter pylori infection in duodenal ulcer patients. Am J Gastroenterol. 1997;92(4):576-81.
Labenz, J., Tillenburg, B., Peitz, U., Börsch, G., Idström, J. P., Verdú, E., Stolte, M., & Blum, A. L. (1997). Efficacy of omeprazole one year after cure of Helicobacter pylori infection in duodenal ulcer patients. The American Journal of Gastroenterology, 92(4), 576-81.
Labenz J, et al. Efficacy of Omeprazole One Year After Cure of Helicobacter Pylori Infection in Duodenal Ulcer Patients. Am J Gastroenterol. 1997;92(4):576-81. PubMed PMID: 9128302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of omeprazole one year after cure of Helicobacter pylori infection in duodenal ulcer patients. AU - Labenz,J, AU - Tillenburg,B, AU - Peitz,U, AU - Börsch,G, AU - Idström,J P, AU - Verdú,E, AU - Stolte,M, AU - Blum,A L, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 576 EP - 81 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 92 IS - 4 N2 - OBJECTIVE: We have previously shown that, in duodenal ulcer patients, pH control by omeprazole is less pronounced after cure of Helicobacter pylori infection. The present study was designed to test the hypothesis that this response to omeprazole persists 1 yr after cure of H. pylori infection. METHODS: In 12 duodenal ulcer patients, intragastric acidity was measured with a glass electrode during treatment with omeprazole (20 mg) once daily before, and 4-6 wk and 1 yr after, cure of H. pylori infection. H. pylori infection was assessed by [13C]urea breath test, culture, histology (Warthin Starry stain), and rapid urease test. RESULTS: Cure of H. pylori infection resulted in a lowered pH during omeprazole treatment. This effect persisted after 1 yr. Median 24-h gastric pH before H. pylori treatment was 5.6; 4-6 wk after cure of the infection it was 2.9 (p = 0.003), and 1 yr after cure of the infection it remained unchanged (pH = 2.5; p = 0.5). Accordingly, twice as much time was spent above pH 3 and pH 4 before H. pylori treatment than 1 or 12 months after cure (percent of time > or = pH 3: 82.7 vs. 49.7 vs. 43.1; percent of time > or = pH 4: 72.7 vs. 38.3 vs. 26.4). CONCLUSION: In duodenal ulcer patients, cure of H. pylori infection resulted in a marked rapid and persistent decrease of the pH increasing effect of omeprazole. Therefore, H. pylori is a determinant of the pH achieved in response to omeprazole treatment in duodenal ulcer patients. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9128302/Efficacy_of_omeprazole_one_year_after_cure_of_Helicobacter_pylori_infection_in_duodenal_ulcer_patients_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -