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Expression of mucin-like carcinoma-associated antigen in the cyst fluid differentiates mucinous from nonmucinous pancreatic cysts.
Am J Gastroenterol. 1997 Apr; 92(4):672-5.AJ

Abstract

OBJECTIVES

Differential diagnosis of pancreatic cystic lesions may be difficult: the main problem is to distinguish mucinous neoplasms from nonmucinous cysts. We evaluated the usefulness of the mucin-like carcinoma-associated antigen (MCA) in the fluid of pancreatic cysts for detecting mucinous neoplasms. Results were compared with those of CA 15-3, carcinoembryonic antigen (CEA), and CA 72-4 fluid content, and cytology.

METHODS

Twenty-four pancreatic cyst fluids were collected from 10 pseudocysts, eight mucinous cystic tumors, and six serous cystadenomas.

RESULTS

MCA was elevated in seven of eight mucinous tumors (sensitivity 87.5%, specificity 100%). A significant difference was found between MCA levels in mucinous neoplasms versus pseudocysts (p = 0.0003) and serous cystadenomas (p = 0.001). Mean MCA levels were higher (133.7 U/ml) in mucinous cystadenocarcinomas than in cystadenomas (37.5 U/ml). The sensitivity of CA 15-3, CEA, and CA 72-4 in detecting mucinous neoplasms was 50, 87.5, and 87.5%, respectively, with a specificity of 94%, 44%, and 94%, respectively. Cytology showed mucinous epithelial cells in only four of eight mucinous neoplasms, with a specificity of 100%.

CONCLUSIONS

These data suggest that MCA determination in the cyst fluid is a promising new tumor marker for the preoperative diagnosis of mucinous cystic neoplasms of the pancreas.

Authors+Show Affiliations

The Department of Surgery, University of Padua, Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9128321

Citation

Sperti, C, et al. "Expression of Mucin-like Carcinoma-associated Antigen in the Cyst Fluid Differentiates Mucinous From Nonmucinous Pancreatic Cysts." The American Journal of Gastroenterology, vol. 92, no. 4, 1997, pp. 672-5.
Sperti C, Pasquali C, Pedrazzoli S, et al. Expression of mucin-like carcinoma-associated antigen in the cyst fluid differentiates mucinous from nonmucinous pancreatic cysts. Am J Gastroenterol. 1997;92(4):672-5.
Sperti, C., Pasquali, C., Pedrazzoli, S., Guolo, P., & Liessi, G. (1997). Expression of mucin-like carcinoma-associated antigen in the cyst fluid differentiates mucinous from nonmucinous pancreatic cysts. The American Journal of Gastroenterology, 92(4), 672-5.
Sperti C, et al. Expression of Mucin-like Carcinoma-associated Antigen in the Cyst Fluid Differentiates Mucinous From Nonmucinous Pancreatic Cysts. Am J Gastroenterol. 1997;92(4):672-5. PubMed PMID: 9128321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of mucin-like carcinoma-associated antigen in the cyst fluid differentiates mucinous from nonmucinous pancreatic cysts. AU - Sperti,C, AU - Pasquali,C, AU - Pedrazzoli,S, AU - Guolo,P, AU - Liessi,G, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 672 EP - 5 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 92 IS - 4 N2 - OBJECTIVES: Differential diagnosis of pancreatic cystic lesions may be difficult: the main problem is to distinguish mucinous neoplasms from nonmucinous cysts. We evaluated the usefulness of the mucin-like carcinoma-associated antigen (MCA) in the fluid of pancreatic cysts for detecting mucinous neoplasms. Results were compared with those of CA 15-3, carcinoembryonic antigen (CEA), and CA 72-4 fluid content, and cytology. METHODS: Twenty-four pancreatic cyst fluids were collected from 10 pseudocysts, eight mucinous cystic tumors, and six serous cystadenomas. RESULTS: MCA was elevated in seven of eight mucinous tumors (sensitivity 87.5%, specificity 100%). A significant difference was found between MCA levels in mucinous neoplasms versus pseudocysts (p = 0.0003) and serous cystadenomas (p = 0.001). Mean MCA levels were higher (133.7 U/ml) in mucinous cystadenocarcinomas than in cystadenomas (37.5 U/ml). The sensitivity of CA 15-3, CEA, and CA 72-4 in detecting mucinous neoplasms was 50, 87.5, and 87.5%, respectively, with a specificity of 94%, 44%, and 94%, respectively. Cytology showed mucinous epithelial cells in only four of eight mucinous neoplasms, with a specificity of 100%. CONCLUSIONS: These data suggest that MCA determination in the cyst fluid is a promising new tumor marker for the preoperative diagnosis of mucinous cystic neoplasms of the pancreas. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9128321/Expression_of_mucin_like_carcinoma_associated_antigen_in_the_cyst_fluid_differentiates_mucinous_from_nonmucinous_pancreatic_cysts_ DB - PRIME DP - Unbound Medicine ER -