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delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain.
Eur J Pharmacol. 1997 Apr 04; 323(2-3):R3-4.EJ

Abstract

We measured the ability of the cannabinoid agonists delta 9-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3- [(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-napht halenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding in mouse brain membranes. delta 9-Tetrahydrocannabinol stimulated [35S]GTP gamma S binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that delta 9-tetrahydrocannabinol acts as a partial agonist in stimulating [35S]GTP gamma S binding in the mouse brain.

Authors+Show Affiliations

Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9128853

Citation

Burkey, T H., et al. "Delta 9-Tetrahydrocannabinol Is a Partial Agonist of Cannabinoid Receptors in Mouse Brain." European Journal of Pharmacology, vol. 323, no. 2-3, 1997, pp. R3-4.
Burkey TH, Quock RM, Consroe P, et al. Delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. Eur J Pharmacol. 1997;323(2-3):R3-4.
Burkey, T. H., Quock, R. M., Consroe, P., Roeske, W. R., & Yamamura, H. I. (1997). Delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. European Journal of Pharmacology, 323(2-3), R3-4.
Burkey TH, et al. Delta 9-Tetrahydrocannabinol Is a Partial Agonist of Cannabinoid Receptors in Mouse Brain. Eur J Pharmacol. 1997 Apr 4;323(2-3):R3-4. PubMed PMID: 9128853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. AU - Burkey,T H, AU - Quock,R M, AU - Consroe,P, AU - Roeske,W R, AU - Yamamura,H I, PY - 1997/4/4/pubmed PY - 1997/4/4/medline PY - 1997/4/4/entrez SP - R3 EP - 4 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 323 IS - 2-3 N2 - We measured the ability of the cannabinoid agonists delta 9-tetrahydrocannabinol and R(+)-[2,3,-dihydro-5-methyl-3- [(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-napht halenyl) methanone mesylate (WIN 55,212-2) to stimulate guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding in mouse brain membranes. delta 9-Tetrahydrocannabinol stimulated [35S]GTP gamma S binding by about 25% as compared to WIN 55,212-2. This is the first report demonstrating that delta 9-tetrahydrocannabinol acts as a partial agonist in stimulating [35S]GTP gamma S binding in the mouse brain. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/9128853/delta_9_Tetrahydrocannabinol_is_a_partial_agonist_of_cannabinoid_receptors_in_mouse_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(97)00146-5 DB - PRIME DP - Unbound Medicine ER -