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Zinc, copper and iron levels in tissues of the vitamin B6 deficient rat.
Int J Vitam Nutr Res 1997; 67(2):102-5IJ

Abstract

Tissue zinc (Zn), copper (Cu) and iron (Fe) were determined in three groups of young male Wistar rats that received a daily pyridoxine hydrochloride (PN.HCl) intake of 45, 23 and 0 micrograms respectively in their diets over 8 weeks. No significant differences were found in the Zn and Cu levels in the liver, kidney, skeletal and cardiac tissue of all 3 groups. The Fe levels were significantly higher in the heart and liver and significantly lower in the skeletal muscle of the group receiving no PN.HCl in the diet (P < 0.05). This study indicates that the increased fecal excretion of Zn and Cu observed during a previous balance study on the above vitamin B6 deficient group of animals may be due to a decreased absorption of these elements from the diet rather than their excretion from tissue stores. The changes in Fe levels in the heart, liver and skeletal muscle points towards some alteration in tissue stores of this element during a vitamin B6 deficiency.

Authors+Show Affiliations

Department of Human Physiology and Physiological Chemistry, University of Durban-Westville, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9129252

Citation

Mackraj, I, et al. "Zinc, Copper and Iron Levels in Tissues of the Vitamin B6 Deficient Rat." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 67, no. 2, 1997, pp. 102-5.
Mackraj I, Channa ML, Burger FJ, et al. Zinc, copper and iron levels in tissues of the vitamin B6 deficient rat. Int J Vitam Nutr Res. 1997;67(2):102-5.
Mackraj, I., Channa, M. L., Burger, F. J., Ubbink, J. B., & Smyth, P. (1997). Zinc, copper and iron levels in tissues of the vitamin B6 deficient rat. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 67(2), pp. 102-5.
Mackraj I, et al. Zinc, Copper and Iron Levels in Tissues of the Vitamin B6 Deficient Rat. Int J Vitam Nutr Res. 1997;67(2):102-5. PubMed PMID: 9129252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc, copper and iron levels in tissues of the vitamin B6 deficient rat. AU - Mackraj,I, AU - Channa,M L, AU - Burger,F J, AU - Ubbink,J B, AU - Smyth,P, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 102 EP - 5 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 67 IS - 2 N2 - Tissue zinc (Zn), copper (Cu) and iron (Fe) were determined in three groups of young male Wistar rats that received a daily pyridoxine hydrochloride (PN.HCl) intake of 45, 23 and 0 micrograms respectively in their diets over 8 weeks. No significant differences were found in the Zn and Cu levels in the liver, kidney, skeletal and cardiac tissue of all 3 groups. The Fe levels were significantly higher in the heart and liver and significantly lower in the skeletal muscle of the group receiving no PN.HCl in the diet (P < 0.05). This study indicates that the increased fecal excretion of Zn and Cu observed during a previous balance study on the above vitamin B6 deficient group of animals may be due to a decreased absorption of these elements from the diet rather than their excretion from tissue stores. The changes in Fe levels in the heart, liver and skeletal muscle points towards some alteration in tissue stores of this element during a vitamin B6 deficiency. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/9129252/Zinc_copper_and_iron_levels_in_tissues_of_the_vitamin_B6_deficient_rat_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -