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Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine.
Agents Actions. 1979 Aug; 9(3):239-43.AA

Abstract

We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes.

Authors

Johnson HG
No affiliation info available
Miller MD
No affiliation info available

MeSH

AnimalsAscitic FluidCalcimycinCalciumChlorpromazineHistamine ReleaseIn Vitro TechniquesLidocaineMast CellsRatsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

91313

Citation

Johnson, H G., and M D. Miller. "Inhibition of Histamine Release and Ionophore-induced Calcium Flux in Rat Mast Cells By Lidocaine and Chlorpromazine." Agents and Actions, vol. 9, no. 3, 1979, pp. 239-43.
Johnson HG, Miller MD. Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine. Agents Actions. 1979;9(3):239-43.
Johnson, H. G., & Miller, M. D. (1979). Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine. Agents and Actions, 9(3), 239-43.
Johnson HG, Miller MD. Inhibition of Histamine Release and Ionophore-induced Calcium Flux in Rat Mast Cells By Lidocaine and Chlorpromazine. Agents Actions. 1979;9(3):239-43. PubMed PMID: 91313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine. AU - Johnson,H G, AU - Miller,M D, PY - 1979/8/1/pubmed PY - 1979/8/1/medline PY - 1979/8/1/entrez SP - 239 EP - 43 JF - Agents and actions JO - Agents Actions VL - 9 IS - 3 N2 - We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/91313/Inhibition_of_histamine_release_and_ionophore_induced_calcium_flux_in_rat_mast_cells_by_lidocaine_and_chlorpromazine_ DB - PRIME DP - Unbound Medicine ER -