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Development of an experimental model of Microsporum canis infection in cats.
Vet Microbiol. 1994 Dec; 42(4):289-95.VM

Abstract

An experimental infection model was developed for reliable induction of Microsporum canis skin infections in cats, using a defined number of macroconidia harvested from the fungus in culture. The strain of M. canis used produced highly fluorescent hairs under ultraviolet illumination. Kittens 8 to 9 weeks of age (n = 6) received 10(5) macroconidia applied topically to a closely-shaved area of skin. Sites were dressed with an occlusive bandage for 3 days, then grooming was restricted for an additional 4 weeks. Lesions were first observed 2 weeks after inoculation, enlarged over the following 6 to 8 weeks, then decreased in size and appeared healed at 12 to 14 weeks after inoculation. Cats often developed satellite lesions on the face, ears, or other body regions. The experimental infections strongly resembled moderately severe cases of naturally-occurring feline dermatophytosis in clinical patients. This experimental infection model will be useful for evaluation of topical and systemic treatments for feline M. canis infection.

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Authors+Show Affiliations

DeBoer DJ
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
Moriello KA
No affiliation info available

MeSH

AnimalsCat DiseasesCatsDermatomycosesMicrosporumTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9133054

Citation

DeBoer, D J., and K A. Moriello. "Development of an Experimental Model of Microsporum Canis Infection in Cats." Veterinary Microbiology, vol. 42, no. 4, 1994, pp. 289-95.
DeBoer DJ, Moriello KA. Development of an experimental model of Microsporum canis infection in cats. Vet Microbiol. 1994;42(4):289-95.
DeBoer, D. J., & Moriello, K. A. (1994). Development of an experimental model of Microsporum canis infection in cats. Veterinary Microbiology, 42(4), 289-95.
DeBoer DJ, Moriello KA. Development of an Experimental Model of Microsporum Canis Infection in Cats. Vet Microbiol. 1994;42(4):289-95. PubMed PMID: 9133054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of an experimental model of Microsporum canis infection in cats. AU - DeBoer,D J, AU - Moriello,K A, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 289 EP - 95 JF - Veterinary microbiology JO - Vet Microbiol VL - 42 IS - 4 N2 - An experimental infection model was developed for reliable induction of Microsporum canis skin infections in cats, using a defined number of macroconidia harvested from the fungus in culture. The strain of M. canis used produced highly fluorescent hairs under ultraviolet illumination. Kittens 8 to 9 weeks of age (n = 6) received 10(5) macroconidia applied topically to a closely-shaved area of skin. Sites were dressed with an occlusive bandage for 3 days, then grooming was restricted for an additional 4 weeks. Lesions were first observed 2 weeks after inoculation, enlarged over the following 6 to 8 weeks, then decreased in size and appeared healed at 12 to 14 weeks after inoculation. Cats often developed satellite lesions on the face, ears, or other body regions. The experimental infections strongly resembled moderately severe cases of naturally-occurring feline dermatophytosis in clinical patients. This experimental infection model will be useful for evaluation of topical and systemic treatments for feline M. canis infection. SN - 0378-1135 UR - https://www.unboundmedicine.com/medline/citation/9133054/Development_of_an_experimental_model_of_Microsporum_canis_infection_in_cats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-1135(94)90060-4 DB - PRIME DP - Unbound Medicine ER -